Frontiers in cancer immunotherapy-a symposium report

被引：47

作者：

Cable, Jennifer ^{[1
]}

Greenbaum, Benjamin ^{[2
]}

Pe'er, Dana ^{[3
,4
]}

Bollard, Catherine M. ^{[5
]}

Bruni, Sofia ^{[6
]}

Griffin, Matthew E. ^{[7
]}

Allison, James P. ^{[8
,9
]}

Wu, Catherine J. ^{[10
,11
,12
,13
,14
]}

Subudhi, Sumit K. ^{[15
]}

Mardis, Elaine R. ^{[16
]}

Brentjens, Renier ^{[17
]}

Sosman, Jeffry A. ^{[18
]}

Cemerski, Saso ^{[19
]}

Zavitsanou, Anastasia-Maria ^{[20
]}

Proia, Theresa ^{[21
]}

Egeblad, Mikala ^{[22
]}

Nolan, Garry ^{[23
,24
,25
]}

Goswami, Sangeeta ^{[15
]}

Spranger, Stefani ^{[26
,27
]}

Mackall, Crystal L. ^{[28
,29
,30
]}

机构：

[1] PhD Sci Writer, New York, NY USA

[2] Mem Sloan Kettering Canc, Computat Oncol, Program Computat Immunooncol, Dept Epidemiol & Biostat, New York, NY USA

[3] Mem Sloan Kettering Canc, Parker Inst Canc Immunotherapy, Program Computat & Syst Biol, New York, NY USA

[4] Mem Sloan Kettering Canc Ctr, Parker Inst Canc Immunotherapy, New York, NY USA

[5] George Washington Univ, Natl Childrens Hosp, Ctr Canc & Immunol Res, Washington, DC USA

[6] Consejo Nacl Invest Cient & Tecn, IBYME, Lab Mol Mech Carcinogenesis, Buenos Aires, DF, Argentina

[7] Rockefeller Univ New York, Lab Chem Biol & Microbial Pathogenesis, New York, NY USA

[8] Univ Texas MD Anderson Canc Ctr, Immunotherapy Platform, Houston, TX 77030 USA

[9] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[10] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[11] MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[12] Harvard Univ, Cambridge, MA 02138 USA

[13] Harvard Med Sch, Boston, MA 02115 USA

[14] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

[15] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA

[16] Nationwide Childrens Hosp, Rasmussen Inst Genom Med, Columbus, OH USA

[17] Mem Sloan Kettering Canc Ctr, Dept Med & Ctr Cell Engn, 1275 York Ave, New York, NY 10021 USA

[18] Northwestern Univ, Div Hematol & Oncol, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

[19] Cue Biopharma, Cambridge, MA USA

[20] NYU, Sch Med, Dept Pathol, New York, NY USA

[21] AstraZeneca, Waltham, MA USA

[22] Canc Ctr, Cold Spring Harbor Lab, New York, NY USA

[23] Stanford Univ, Baxter Lab Stem Cell Biol, Stanford, CA 94305 USA

[24] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[25] Parker Inst Canc Immunotherapy, San Francisco, CA USA

[26] MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[27] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[28] Stanford Canc Inst, Ctr Canc Cell Therapy, Stanford, CA USA

[29] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA

[30] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2021年 / 1489卷 / 01期

关键词：

cancer vaccine; CAR T; checkpoint inhibitors; immune evasion; immuno‐ oncology; immunogenomics; immunotherapy; neoantigen; T cell therapy; tumor microenvironment; T-CELL THERAPY; RESISTANT PROSTATE-CANCER; IMMUNE CHECKPOINT; LYMPHOPROLIFERATIVE DISEASE; DOUBLE-BLIND; LUNG-CANCER; CAR THERAPY; EBV; IPILIMUMAB; ANTIGEN;

D O I：

10.1111/nyas.14526

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cancer immunotherapy has dramatically changed the approach to cancer treatment. The aim of targeting the immune system to recognize and destroy cancer cells has afforded many patients the prospect of achieving deep, long-term remission and potential cures. However, many challenges remain for achieving the goal of effective immunotherapy for all cancer patients. Checkpoint inhibitors have been able to achieve long-term responses in a minority of patients, yet improving response rates with combination therapies increases the possibility of toxicity. Chimeric antigen receptor T cells have demonstrated high response rates in hematological cancers, although most patients experience relapse. In addition, some cancers are notoriously immunologically "cold" and typically are not effective targets for immunotherapy. Overcoming these obstacles will require new strategies to improve upon the efficacy of current agents, identify biomarkers to select appropriate therapies, and discover new modalities to expand the accessibility of immunotherapy to additional tumor types and patient populations.

引用

页码：30 / 47

页数：18

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