Clinical trials for pediatric traumatic brain injury: definition of insanity?

被引：21
作者：
Appavu, Brian [1 ,2 ]
Foldes, Stephen T. [1 ]
Adelson, P. David [1 ,2 ]
机构：
[1] Barrow Neurol Inst, Phoenix Childrens Hosp, Phoenix, AZ 85013 USA
[2] Univ Arizona, Coll Med Phoenix, Dept Child Hlth, Phoenix, AZ USA
来源：
JOURNAL OF NEUROSURGERY-PEDIATRICS | 2019年 / 23卷 / 06期
关键词：
clinical trials; multimodality monitoring; autoregulation; traumatic brain injury; trauma; EARLY DECOMPRESSIVE CRANIECTOMY; PHASE-II; INTRACRANIAL HYPERTENSION; MODERATE HYPOTHERMIA; HYPERTONIC SALINE; CHILDREN; PRESSURE; SCALE; CARE; AUTOREGULATION;
D O I：
10.3171/2019.2.PEDS18384
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children both in the United States and throughout the world. Despite valiant efforts and multiple clinical trials completed over the last few decades, there are no high-level recommendations for pediatric TBI available in current guidelines. In this review, the authors explore key findings from the major pediatric clinical trials in children with TBI that have shaped present-day recommendations and the insights gained from them. The authors also offer a perspective on potential efforts to improve the efficacy of future clinical trials in children following TBI.
引用
收藏
页码：661 / 669
页数：9
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