Complex Chemosensory Control of Female Reproductive Behaviors
被引:45
作者:
Fraser, Eleanor J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Anat, Genet Program, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Anat, Genet Program, San Francisco, CA 94143 USA
Fraser, Eleanor J.
[1
]
Shah, Nirao M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Anat, Genet Program, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Anat, Genet Program, San Francisco, CA 94143 USA
Shah, Nirao M.
[1
]
机构:
[1] Univ Calif San Francisco, Dept Anat, Genet Program, San Francisco, CA 94143 USA
Olfaction exerts a profound influence on reproductive physiology and behavior in many animals, including rodents. Odors are recognized by sensory neurons residing in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO) in mice and many other vertebrates. The relative contributions of the MOE and VNO in the display of female behaviors are not well understood. Mice null for Cnga2 or Trpc2 essentially lack odor-evoked activity in the MOE and VNO, respectively. Using females mutant for one or both of Cnga2 and Trpc2, we find that maternal care is differentially regulated by the MOE and VNO: retrieval of wandering pups requires the MOE and is regulated redundantly by the VNO whereas maternal aggression requires both sensory epithelia to be functional. Female sexual receptivity appears to be regulated by both the MOE and VNO. Trpc2 null females have previously been shown to display male-type mounting towards other males. Remarkably, we find that females double mutant for Cnga2 and Trpc2 continue to mount other males, indicating that the disinhibition of male-type sexual displays observed in Trpc2 null females does not require chemosensory input from a functional MOE. Taken together, our findings reveal a previously unappreciated complexity in the chemosensory control of reproductive behaviors in the female mouse.
机构:Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA
Belluscio, L
;
Gold, GH
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA
Gold, GH
;
Nemes, A
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA
Nemes, A
;
Axel, R
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA
机构:Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA
Belluscio, L
;
Gold, GH
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA
Gold, GH
;
Nemes, A
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA
Nemes, A
;
Axel, R
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA