Complex Chemosensory Control of Female Reproductive Behaviors

被引:45
作者
Fraser, Eleanor J. [1 ]
Shah, Nirao M. [1 ]
机构
[1] Univ Calif San Francisco, Dept Anat, Genet Program, San Francisco, CA 94143 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
MAIN OLFACTORY EPITHELIUM; TYPE-3; ADENYLYL-CYCLASE; VOMERONASAL ORGAN; SEXUAL-BEHAVIOR; MICE DEFICIENT; MUTANT MICE; PHEROMONE; MOUSE; AGGRESSION; CHANNEL;
D O I
10.1371/journal.pone.0090368
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Olfaction exerts a profound influence on reproductive physiology and behavior in many animals, including rodents. Odors are recognized by sensory neurons residing in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO) in mice and many other vertebrates. The relative contributions of the MOE and VNO in the display of female behaviors are not well understood. Mice null for Cnga2 or Trpc2 essentially lack odor-evoked activity in the MOE and VNO, respectively. Using females mutant for one or both of Cnga2 and Trpc2, we find that maternal care is differentially regulated by the MOE and VNO: retrieval of wandering pups requires the MOE and is regulated redundantly by the VNO whereas maternal aggression requires both sensory epithelia to be functional. Female sexual receptivity appears to be regulated by both the MOE and VNO. Trpc2 null females have previously been shown to display male-type mounting towards other males. Remarkably, we find that females double mutant for Cnga2 and Trpc2 continue to mount other males, indicating that the disinhibition of male-type sexual displays observed in Trpc2 null females does not require chemosensory input from a functional MOE. Taken together, our findings reveal a previously unappreciated complexity in the chemosensory control of reproductive behaviors in the female mouse.
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页数:6
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