Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma

被引：41
作者：
Soriani, Alessandra [1 ]
Fionda, Cinzia [1 ]
Ricci, Biancamaria [1 ]
Iannitto, Maria Luisa [1 ]
Cippitelli, Marco [1 ]
Santoni, Angela [1 ]
机构：
[1] Univ Roma La Sapienza, Ist Pasteur Fdn Cenci Bolognetti, Dept Mol Med, I-00185 Rome, Italy
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 12期
关键词：
DNAM-1; multiple myeloma; NK cells; NKG2D; tumor immunology; CELLS; CANCER; SURVEILLANCE; SENESCENCE; MICE;
D O I：
10.4161/onci.26663
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Malignant cells constitutively express Natural killer group 2, member D (NKG2D) or DNAX Accessory Molecule-1 (DNAM-1) ligands, yet they are often unable to trigger a robust cytotoxic cell response. It may be therapeutically useful to implement strategies aimed at increasing the density of NKG2D and DNAM-1 ligands on the surface of cancer cells, endowing them with the capacity to activate potent antitumor natural killer-cell responses.
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