Nonribosomal peptide biosynthesis:: Point mutations and module skipping lead to chemical diversity

被引：75
作者：
Wenzel, SC
Meiser, P
Binz, TM
Mahmud, T
Müller, R
机构：
[1] Univ Saarland, D-66041 Saarbrucken, Germany
[2] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 14期
关键词：
biosynthesis; module skipping; myxobacteria; natural products; peptides;
D O I：
10.1002/anie.200503737
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Big effects from small changes: In a comparative analysis of the nonribosomal peptide synthetases (NRPSs) from the biosynthetic pathways of two highly related myxobacterial lipopeptides, module skipping and point mutations are directly correlated to structural variations in these natural products. The skipping process during myxochromide S biosynthesis was characterized biochemically and represents the first example of a module skipping in NRPS systems. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：2296 / 2301
页数：6
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