T Cell-Mediated Host Immune Defenses in the Lung

被引：172

作者：

Chen, Kong ^{[1
]}

Kolls, Jay K. ^{[1
]}

机构：

[1] UPMC, Childrens Hosp Pittsburgh, Richard King Mellon Fdn, Pediat Res Inst, Pittsburgh, PA 15201 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 | 2013年 / 31卷

关键词：

pneumonia; inflammation; coinfection; INFLUENZA-VIRUS INFECTION; PNEUMOCYSTIS-CARINII-PNEUMONIA; MYCOBACTERIUM-TUBERCULOSIS INFECTION; RESISTANT PULMONARY TUBERCULOSIS; VACCINE-INDUCED PROTECTION; ADJUVANT INTERFERON-GAMMA; COLONY-STIMULATING FACTOR; BACILLE CALMETTE-GUERIN; TGF-BETA; ASPERGILLUS-FUMIGATUS;

D O I：

10.1146/annurev-immunol-032712-100019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Evidence has increasingly shown that the lungs are a major site of immune regulation. A robust and highly regulated immune response in the lung protects the host from pathogen infection, whereas an inefficient or deleterious response can lead to various pulmonary diseases. Many cell types, such as epithelial cells, dendritic cells, macrophages, neutrophils, eosinophils, and B and T lymphocytes, contribute to lung immunity. This review focuses on the recent advances in understanding how T lymphocytes mediate pulmonary host defenses against bacterial, viral, and fungal pathogens.

引用

收藏

页码：605 / 633

页数：29

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