The Inhibitory Effect of Ellagic Acid on Cell Growth of Ovarian Carcinoma Cells

被引：54

作者：

Chung, Yuan-Chiang ^{[1
]}

Lu, Li-Cheng ^{[2
]}

Tsai, Ming-Hsiu ^{[3
]}

Chen, Yu-Jen ^{[3
]}

Chen, Yi-Ying ^{[3
]}

Yao, Shih-Ping ^{[3
]}

Hsu, Chih-Ping ^{[3
]}

机构：

[1] Cheng Ching Hosp, Dept Surg, Chung Kang Branch, Taichung 40764, Taiwan

[2] Taoyuan Gen Hosp, Dept Obstet & Gynecol, Dept Hlth, Tao Yuan 33004, Taiwan

[3] Yuanpei Univ, Dept Med Lab Sci & Biotechnol, Hsinchu 30015, Taiwan

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷

关键词：

THERAPEUTIC TARGET; CANCER; APOPTOSIS; AUTOPHAGY; PROTEIN; KINASE; PROLIFERATION; EXPRESSION; PROGNOSIS;

D O I：

10.1155/2013/306705

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Ellagic acid (EA) is able to inhibit the growth of several cancer cells; however, its effect on human ovarian carcinoma cells has not yet been investigated. Ovarian carcinoma ES-2 and PA-1 cells were treated with EA (10 similar to 100 mu M) and assessed for viability, cell cycle, apoptosis, anoikis, autophagy, and chemosensitivity to doxorubicin and their molecular mechanisms. EA inhibited cell proliferation in a dose-and time-dependent manner by arresting both cell lines at the G1 phase of the cell cycle, which were from elevating p53 and Cip1/p21 and decreasing cyclin D1 and E levels. EA also induced caspase-3-mediated apoptosis by increasing the Bax : Bcl-2 ratio and restored anoikis in both cell lines. The enhancement of apoptosis and/or inhibition of autophagy in these cells by EA assisted the chemotherapy efficacy. The results indicated that EA is a potential novel chemoprevention and treatment assistant agent for human ovarian carcinoma.

引用

页数：12

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