Th17 cells in renal inflammation and autoimmunity

被引：73

作者：

Dolff, Sebastian ^{[1
]}

Witzke, Oliver ^{[1
]}

Wilde, Benjamin ^{[2
]}

机构：

[1] Univ Duisburg Essen, Univ Hosp Essen, Dept Infect Dis, Essen, Germany

[2] Univ Duisburg Essen, Univ Hosp Essen, Dept Nephrol, Hufelandstr 55, D-45122 Essen, Germany

来源：

AUTOIMMUNITY REVIEWS | 2019年 / 18卷 / 02期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANTIBODY-ASSOCIATED VASCULITIS; TUBULAR EPITHELIAL-CELLS; REGULATORY T-CELLS; WEGENERS-GRANULOMATOSIS; STAPHYLOCOCCUS-AUREUS; DISEASE-ACTIVITY; IL-17; EXPRESSION; IN-VITRO; ANCA;

D O I：

10.1016/j.autrev.2018.08.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Th17 cells are a distinct lineage of T-cells. These T-cells express IL-17A and the lineage-defining transcription factor ROR gamma t. Th17 cells have a pivotal, physiological role in host defense against pathogens. These pro-inflammatory T-cells are also key players in autoimmunity and a pathogenic role has been demonstrated in several diseases such as rheumatoid arthritis or psoriasis. Recently, there is evidence that Th17 cells may drive renal inflammation and renal autoimmunity in anti-neutrophil-cytoplasmic-antibody-(ANCA)-vasculitis and systemic lupus erythematosus. The aim of this review is to discuss the possible involvement of Th17 cells in renal autoimmunity and its value for future therapeutic approaches.

引用

收藏

页码：129 / 136

页数：8

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