Th17 cells in renal inflammation and autoimmunity

被引：73
作者：
Dolff, Sebastian [1 ]
Witzke, Oliver [1 ]
Wilde, Benjamin [2 ]
机构：
[1] Univ Duisburg Essen, Univ Hosp Essen, Dept Infect Dis, Essen, Germany
[2] Univ Duisburg Essen, Univ Hosp Essen, Dept Nephrol, Hufelandstr 55, D-45122 Essen, Germany
来源：
AUTOIMMUNITY REVIEWS | 2019年 / 18卷 / 02期
关键词：
SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANTIBODY-ASSOCIATED VASCULITIS; TUBULAR EPITHELIAL-CELLS; REGULATORY T-CELLS; WEGENERS-GRANULOMATOSIS; STAPHYLOCOCCUS-AUREUS; DISEASE-ACTIVITY; IL-17; EXPRESSION; IN-VITRO; ANCA;
D O I：
10.1016/j.autrev.2018.08.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Th17 cells are a distinct lineage of T-cells. These T-cells express IL-17A and the lineage-defining transcription factor ROR gamma t. Th17 cells have a pivotal, physiological role in host defense against pathogens. These pro-inflammatory T-cells are also key players in autoimmunity and a pathogenic role has been demonstrated in several diseases such as rheumatoid arthritis or psoriasis. Recently, there is evidence that Th17 cells may drive renal inflammation and renal autoimmunity in anti-neutrophil-cytoplasmic-antibody-(ANCA)-vasculitis and systemic lupus erythematosus. The aim of this review is to discuss the possible involvement of Th17 cells in renal autoimmunity and its value for future therapeutic approaches.
引用
收藏
页码：129 / 136
页数：8
相关论文
共 109 条
[1]   Persistent expansion of CD4+ effector memory T cells in Wegener's granulomatosis [J].
Abdulahad, W. H. ;
van der Geld, Y. M. ;
Stegeman, C. A. ;
Kallenberg, C. G. M. .
KIDNEY INTERNATIONAL, 2006, 70 (05) :938-947
[2]   Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission [J].
Abdulahad, Wayel H. ;
Stegeman, Coen A. ;
Limburg, Pieter C. ;
Kallenberg, Cees G. A. .
ARTHRITIS AND RHEUMATISM, 2008, 58 (07) :2196-2205
[3]   Functional defect of circulating regulatory CD4+T cells in patients with Wegener's granulomatosis in remission [J].
Abdulahad, Wayel H. ;
Stegeman, Coen A. ;
van der Geld, Ymke M. ;
Doornbos-van der Meer, Berber ;
Limburg, Pieter C. ;
Kallenberg, Cees G. M. .
ARTHRITIS AND RHEUMATISM, 2007, 56 (06) :2080-2091
[4]   IL-17 Signaling: The Yin and the Yang [J].
Amatya, Nilesh ;
Garg, Abhishek V. ;
Gaffen, Sarah L. .
TRENDS IN IMMUNOLOGY, 2017, 38 (05) :310-322
[5]  
Aten J, 2000, J AM SOC NEPHROL, V11, P1426, DOI 10.1681/ASN.V1181426
[6]   CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients [J].
Blair, Paul A. ;
Norena, Lina Yassin ;
Flores-Borja, Fabian ;
Rawlings, David J. ;
Isenberg, David A. ;
Ehrenstein, Michael R. ;
Mauri, Claudia .
IMMUNITY, 2010, 32 (01) :129-140
[7]   The functional plasticity of T cell subsets [J].
Bluestone, Jeffrey A. ;
Mackay, Charles R. ;
O'Shea, John J. ;
Stockinger, Brigitta .
NATURE REVIEWS IMMUNOLOGY, 2009, 9 (11) :811-816
[8]  
BROUWER E, 1991, CLIN EXP IMMUNOL, V83, P379
[9]   Protective effect of 1α, 25-dihydroxyvitamin D3 on effector CD4+ T cell induced injury in human renal proximal tubular epithelial cells [J].
Chung, Byung Ha ;
Kim, Bo-Mi ;
Doh, Kyoung Chan ;
Cho, Mi-La ;
Kim, Kyoung Woon ;
Yang, Chul Woo .
PLOS ONE, 2017, 12 (02)
[10]   T cell contributions to the different phases of granuloma formation [J].
Co, DO ;
Hogan, LH ;
Il-Kim, S ;
Sandor, M .
IMMUNOLOGY LETTERS, 2004, 92 (1-2) :135-142
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