Simultaneous Voltammetric Determination of Captopril and Hydrochlorothiazide on a Graphene/Ferrocene Composite Carbon Paste Electrode

被引：41

作者：

Gholivand, Mohammad Bagher ^{[1
]}

Khodadadian, Mehdi ^{[1
]}

机构：

[1] Razi Univ, Dept Analyt Chem, Fac Chem, Kermanshah, Iran

来源：

ELECTROANALYSIS | 2013年 / 25卷 / 05期

关键词：

Graphene; Ferrocene; Captopril; Hydrochlorothiazide; Electrocatalytic oxidation; LIQUID-CHROMATOGRAPHIC DETERMINATION; ANGIOTENSIN-CONVERTING ENZYME; SENSOR; NANOTUBES; CHEMILUMINESCENCE; PENICILLAMINE; FERROCENE; BIOSENSOR; URINE; ACID;

D O I：

10.1002/elan.201200665

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this work, a voltammetric method has been developed for the simultaneous determination of captopril (CPT) and hydrochlorothiazide (HCT) in pharmaceutical combinations and clinical samples using a graphene/ferrocene composite carbon paste (GR/Fc/CP) electrode. The electrochemical behaviors of CPT and HCT were individually and simultaneously investigated at the surface of the GR/Fc/CP electrode. In differential pulse voltammetric (DPV) mode and under optimized experimental conditions, CPT and HCT gave linear responses over the concentration ranges 1.0430 mu M and 0.5390 mu M (r2>0.99), respectively. The prepared electrode could be used for simultaneous determination of CPT and HCT in some real samples.

引用

页码：1263 / 1270

页数：8

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