Helminth mediated modulation of Type 1 diabetes (T1D)

被引：18
作者：
Zaccone, Paola [1 ]
Cooke, Anne [1 ]
机构：
[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England
来源：
INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2013年 / 43卷 / 3-4期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
Type; 1; diabetes; Helminth; NKT; Regulatory T cells; IL-10; TGF-beta; REGULATORY T-CELLS; SCHISTOSOMA-MANSONI ANTIGENS; PRONE NOD MICE; DENDRITIC CELLS; NKT CELLS; AUTOIMMUNE-DISEASE; IMMUNE-RESPONSES; ROTAVIRUS INFECTION; TH2; POLARIZATION; VIRUS-INFECTION;
D O I：
10.1016/j.ijpara.2012.12.004
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Type 1 diabetes is increasing dramatically in incidence in the developed world. While there may be several reasons for this, improved sanitation and public health measures have altered our interactions with certain infectious agents such as helminths. There is increasing interest in the use of helminths or their products to,alleviate inflammatory or allergic conditions. Using rodent models of diabetes, it has been possible to explore the therapeutic potential of both live infections as well as helminth-derived products on the development of autoimmunity. This review provides an overview of the findings from animal models and additionally explores the potential for translation to the clinic. (C) 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：311 / 318
页数：8
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