Association of functional variants of PTPN22 and tp53 in psoriatic arthritis:: a case-control study

被引：23

作者：

Butt, C

Peddle, L

Greenwood, C

Hamilton, S

Gladman, D

Rahman, P ^{[1
]}

机构：

[1] Mem Univ Newfoundland, Hosp Sick Children, Dept Publ Hlth Sci, Univ Toronto, Toronto, ON, Canada

[2] Univ Toronto, Hosp Sick Children, Dept Publ Hlth Sci, Toronto, ON, Canada

[3] Univ Toronto, Toronto Western Hosp, Univ Hlth Network, Toronto, ON, Canada

来源：

ARTHRITIS RESEARCH & THERAPY | 2006年 / 8卷 / 01期

关键词：

D O I：

10.1186/ar1880

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland, Canada and an admixed Caucasian PsA cohort from Toronto, Canada. We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted.

引用

页数：3

共 14 条

[1] A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis [J].

Begovich, AB ;

Carlton, VEH ;

Honigberg, LA ;

Schrodi, SJ ;

Chokkalingam, AP ;

Alexander, HC ;

Ardlie, KG ;

Huang, QQ ;

Smith, AM ;

Spoerke, JM ;

Conn, MT ;

Chang, M ;

Chang, SYP ;

Saiki, RK ;

Catanese, JJ ;

Leong, DU ;

Garcia, VE ;

McAllister, LB ;

Jeffery, DA ;

Lee, AT ;

Batliwalla, F ;

Remmers, E ;

Criswell, LA ;

Seldin, MF ;

Kastner, DL ;

Amos, CI ;

Sninsky, JJ ;

Gregersen, PK .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (02) :330-337

[2] A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes [J].

Bottini, N ;

Musumeci, L ;

Alonso, A ;

Rahmouni, S ;

Nika, K ;

Rostamkhani, M ;

MacMurray, J ;

Meloni, GF ;

Lucarelli, P ;

Pellecchia, M ;

Eisenbarth, GS ;

Comings, D ;

Mustelin, T .

NATURE GENETICS, 2004, 36 (04) :337-338

[3] Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection:: the PTPN22 620W allele associates with multiple autoimmune phenotypes [J].

Criswell, LA ;

Pfeiffer, KA ;

Lum, RF ;

Gonzales, B ;

Novitzke, J ;

Moser, KL ;

Begovich, AB ;

Carlton, VEH ;

Li, W ;

Lee, AT ;

Ortmann, W ;

Behrens, TW ;

Gregersen, PK .

AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (04) :561-571

[4]

Firestein GS, 1996, AM J PATHOL, V149, P2143

[5]

Hannuksela-Svahn A, 1999, ACTA DERM-VENEREOL, V79, P195

[6] PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells [J].

Hasegawa, K ;

Martin, F ;

Huang, GM ;

Tumas, D ;

Diehl, L ;

Chan, AC .

SCIENCE, 2004, 303 (5658) :685-689

[7] Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE [J].

Kyogoku, C ;

Langefeld, CD ;

Ortmann, WA ;

Lee, A ;

Selby, S ;

Carlton, VEH ;

Chang, M ;

Ramos, P ;

Baechler, EC ;

Batliwalla, FM ;

Novitzke, J ;

Williams, AH ;

Gillett, C ;

Rodine, P ;

Graham, RR ;

Ardlie, KG ;

Gaffney, PM ;

Moser, KL ;

Petri, M ;

Begovich, AB ;

Gregersen, PK ;

Behrens, TW .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (03) :504-507

[8]

Lee YH, 2001, J RHEUMATOL, V28, P2392

[9] Reduced p53 in peripheral blood mononuclear cells from patients with rheumatoid arthritis is associated with loss of radiation-induced apoptosis [J].

Maas, K ;

Westfall, M ;

Pietenpol, J ;

Olsen, NJ ;

Aune, T .

ARTHRITIS AND RHEUMATISM, 2005, 52 (04) :1047-1057

[10] Protein tyrosine phosphatase gene PTPN22 polymorphism in psoriasis: Lack of evidence for association [J].

Nistor, I ;

Nair, RP ;

Stuart, P ;

Hiremagalore, R ;

Thompson, RA ;

Jenisch, S ;

Weichenthal, M ;

Abecasis, GR ;

Qin, ZS ;

Christophers, E ;

Lim, HW ;

Voorhees, JJ ;

Elder, JT .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 125 (02) :395-396

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