共 22 条
Characterization of skin Th17 transcriptional profiles in psoriatic patients under adalimumab biotherapy
被引:2
作者:

Buffiere-Morgado, Amandine
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h-index: 0
机构:
CHU Poitiers, F-86021 Poitiers, France
Univ Poitiers, Lab Inflammat Tissus Epitheliaux & Cytokines, F-86073 Poitiers, France CHU Poitiers, F-86021 Poitiers, France

Couderc, Elodie
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h-index: 0
机构:
CHU Poitiers, F-86021 Poitiers, France
Univ Poitiers, Lab Inflammat Tissus Epitheliaux & Cytokines, F-86073 Poitiers, France CHU Poitiers, F-86021 Poitiers, France

Delwail, Adriana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, ImageUP, STIM, ERL 7368, F-86073 Poitiers, France CHU Poitiers, F-86021 Poitiers, France

Favot, Laure
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Lab Inflammat Tissus Epitheliaux & Cytokines, F-86073 Poitiers, France CHU Poitiers, F-86021 Poitiers, France

Jegou, Jean-Francois
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机构:
Univ Poitiers, Lab Inflammat Tissus Epitheliaux & Cytokines, F-86073 Poitiers, France CHU Poitiers, F-86021 Poitiers, France

Solau, Elisabeth
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Poitiers, F-86021 Poitiers, France
Univ Poitiers, Lab Inflammat Tissus Epitheliaux & Cytokines, F-86073 Poitiers, France CHU Poitiers, F-86021 Poitiers, France

Guillet, Gerard
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Poitiers, F-86021 Poitiers, France
Univ Poitiers, Lab Inflammat Tissus Epitheliaux & Cytokines, F-86073 Poitiers, France CHU Poitiers, F-86021 Poitiers, France

Lecron, Jean-Claude
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Poitiers, F-86021 Poitiers, France
Univ Poitiers, Lab Inflammat Tissus Epitheliaux & Cytokines, F-86073 Poitiers, France CHU Poitiers, F-86021 Poitiers, France

Morel, Frank
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Lab Inflammat Tissus Epitheliaux & Cytokines, F-86073 Poitiers, France CHU Poitiers, F-86021 Poitiers, France
机构:
[1] CHU Poitiers, F-86021 Poitiers, France
[2] Univ Poitiers, Lab Inflammat Tissus Epitheliaux & Cytokines, F-86073 Poitiers, France
[3] Univ Poitiers, ImageUP, STIM, ERL 7368, F-86073 Poitiers, France
关键词:
cytokine;
inflammation;
psoriasis;
biotherapy;
adalimumab;
TNF-ALPHA;
EPIDERMAL HYPERPLASIA;
ONCOSTATIN-M;
EXPRESSION;
INFLAMMATION;
ETANERCEPT;
INHIBITION;
EFFICACY;
THERAPY;
MECHANISMS;
D O I:
10.1684/ejd.2017.3127
中图分类号:
R75 [皮肤病学与性病学];
学科分类号:
100206 ;
摘要:
Background: In psoriasis, a specific cytokine network has been described to play a central role in the pathophysiology of the disease. Anti-cytokine therapeutic approaches have been largely developed and TNF alpha constitutes the main target. Adalimumab is a human anti-TNF alpha monoclonal antibody that has been reported to demonstrate clinical efficacy and safety, resulting in reversal of epidermal hyperplasia and cutaneous inflammation. Objectives: We aimed to analyse changes in the skin inflammatory transcriptomic profile in psoriatic patients during adalimumab therapy. In addition, the circulating cytokine profile was analysed to define systemic inflammation. Materials&methods: Eighteen patients with chronic plaque psoriasis were treated with adalimumab. After four and 16 weeks, clinical efficacy was assessed using PASI and DLQI, and skin mRNA profiles were determined and circulating cytokines quantified. Results: We identified a rapid effect of adalimumab therapy on a large array of Th17 cytokines of the skin, which may account for the modification of keratinocyte expression profile and clinical response. In contrast, analysis of serum cytokine concentrations was uninformative, confirming the need for characterization of local cytokines in skin lesions. Finally, in non-responders, local cytokine expression was shown to be unchanged. Conclusion: We show that TNF alpha inhibition in psoriasis patients treated with adalimumab has a broad effect on the expression profile of cytokines and keratinocyte markers of skin inflammation, which may account for its clinical efficacy.
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页码:579 / 589
页数:11
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BIOalternatives, Gencay, France Univ Poitiers, Lab Inflammat Tissus Epitheliaux & Cytokines, UPRES, Unites Propres Rech Equipe Accueil,EA 4331, F-86022 Poitiers, France

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h-index:
机构:

Guzman, A. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA

Swindell, W. R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA

Wang, F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA

Kang, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Med, Dept Dermatol, Baltimore, MD USA Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA

Gudjonsson, J. E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
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Immunology of Psoriasis
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Lowes, Michelle A.
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Rockefeller Univ, Lab Invest Dermatol, New York, NY 10065 USA Rockefeller Univ, Lab Invest Dermatol, New York, NY 10065 USA

Suarez-Farinas, Mayte
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Invest Dermatol, New York, NY 10065 USA Rockefeller Univ, Lab Invest Dermatol, New York, NY 10065 USA

Krueger, James G.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Invest Dermatol, New York, NY 10065 USA Rockefeller Univ, Lab Invest Dermatol, New York, NY 10065 USA