Ru-catalyzed synthesis of substituted phthalides through C-H bond activation and functionalization

被引：6

作者：

Kianmehr, Ebrahim ^{[1
]}

Fardpour, Maryam ^{[1
]}

Darvish, Ali ^{[1
]}

Kharat, Ali Nemati ^{[1
]}

Ng, Seik Weng ^{[2
]}

机构：

[1] Univ Tehran, Coll Sci, Sch Chem, Tehran, Iran

[2] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 10期

基金：

美国国家科学基金会;

关键词：

Cross-coupling reaction; C-H activation; Ruthenium-catalyzed; Phthalide; Phthalic anhydride; BENZOIC-ACIDS; CARBOXYLIC-ACIDS; DIRECT ARYLATION; PALLADIUM; ALKYNES; OLEFINATION; ALKENYLATIONS; HETEROCYCLES; ISOCOUMARINS; DERIVATIVES;

D O I：

10.1016/j.tetlet.2018.12.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of substituted phthalides through a ruthenium-catalyzed reaction of phthalic anhydrides with acrylates is described. The reaction proceeds via C-H bond activation and leads to the formation of vinylated phthalides through a successive double vinylation accompanied by decarboxylation and annulation reactions. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：699 / 702

页数：4

共 53 条

[51] Catalytic Enantioselective Synthesis of Chiral Phthalides by Efficient Reductive Cyclization of 2-Acylarylcarboxylates under Aqueous Transfer Hydrogenation Conditions [J].