Ru-catalyzed synthesis of substituted phthalides through C-H bond activation and functionalization

被引：6
作者：
Kianmehr, Ebrahim [1 ]
Fardpour, Maryam [1 ]
Darvish, Ali [1 ]
Kharat, Ali Nemati [1 ]
Ng, Seik Weng [2 ]
机构：
[1] Univ Tehran, Coll Sci, Sch Chem, Tehran, Iran
[2] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 10期
基金：
美国国家科学基金会;
关键词：
Cross-coupling reaction; C-H activation; Ruthenium-catalyzed; Phthalide; Phthalic anhydride; BENZOIC-ACIDS; CARBOXYLIC-ACIDS; DIRECT ARYLATION; PALLADIUM; ALKYNES; OLEFINATION; ALKENYLATIONS; HETEROCYCLES; ISOCOUMARINS; DERIVATIVES;
D O I：
10.1016/j.tetlet.2018.12.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of substituted phthalides through a ruthenium-catalyzed reaction of phthalic anhydrides with acrylates is described. The reaction proceeds via C-H bond activation and leads to the formation of vinylated phthalides through a successive double vinylation accompanied by decarboxylation and annulation reactions. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：699 / 702
页数：4
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