Oophorectomy hinders antioxidant adaptation promoted by swimming in Wistar rats

被引：7

作者：

de Oliveira Macedo, Ulisvaldo Brunno ^{[1
]}

Martins, Rand Randall ^{[2
]}

Freire Neto, Francisco Paulo ^{[1
]}

da Costa Oliveira, Yonara Monique ^{[1
]}

Medeiros, Aldo da Cunha ^{[3
]}

Brandao-Neto, Jose ^{[4
]}

de Rezende, Adriana Augusto ^{[5
]}

Almeida, Maria das Gracas ^{[5
]}

机构：

[1] Fed Univ Rio Grande Norte UFRN, Postgrad Pharmaceut Sci Program, Natal, RN, Brazil

[2] UFCG, Educ & Hlth Ctr, Cuite, Brazil

[3] Univ Fed Rio Grande do Norte, Dept Surg, BR-59012570 Natal, RN, Brazil

[4] Univ Fed Rio Grande do Norte, Dept Clin Med, BR-59012570 Natal, RN, Brazil

[5] Univ Fed Rio Grande do Norte, Dept Clin & Toxicol Anal, BR-59012570 Natal, RN, Brazil

来源：

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2013年 / 38卷 / 02期

关键词：

oophorectomy; menopause; oxidative stress; physical exercise; OXIDATIVE STRESS; ESTROGEN-RECEPTOR; EXERCISE; HEALTHY; DISEASE; MARKERS;

D O I：

10.1139/apnm-2012-0121

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Oxidative stress is associated with postmenopause and is also responsible for various metabolic alterations. The redox imbalance observed during ovarian decline can be induced experimentally by bilateral ovariectomy in rats. In addition to hormone replacement, regular moderate physical exercise is indicated to prevent several common postmenopausal diseases. This study aimed to assess the effect of daily swimming on the antioxidant defense system of oophorectomized Wistar rats. Control and oophorectomized groups were submitted to 1 h of daily swimming for 90 days. Levels of lipid peroxidation and glutathione content and the activities of superoxide dismutase enzyme and glutathione peroxidase in erythrocytes, liver, and brain were assessed every 30 days. The control group exhibited lower lipoperoxidation that was associated with a significant increase in superoxide dismutase enzyme activity, glutathione peroxidase activity, and glutathione content in erythrocytes and liver; however, swimming did not cause changes in antioxidant parameters in the brain over time. The oophorectomized group showed no antioxidant adaptation to daily swimming and had greater oxidative damage in the liver and blood. Our results suggest that ovariectomy hinders antioxidant adaptation in Wistar rats submitted to daily swimming.

引用

页码：148 / 153

页数：6

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