Graft versus tumor effect in the brain of a child with recurrent metastatic medulloblastoma

被引：4

作者：

Abdel-Azim, Hisham ^{[1
]}

Kapoor, Neena ^{[1
]}

Mahadeo, Kris M. ^{[2
]}

Finlay, Jonathan L. ^{[3
,4
]}

机构：

[1] Univ So Calif, Childrens Hosp Angeles, Div Hematol Oncol Blood & Marrow Transplantat, Los Angeles, CA 90027 USA

[2] Albert Einstein Coll Med, Childrens Hosp Montefiore, Bronx, NY 10467 USA

[3] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA

[4] Ohio State Univ, BMT, Nationwide Childrens Hosp, Columbus, OH 43210 USA

来源：

PEDIATRIC BLOOD & CANCER | 2015年 / 62卷 / 09期

关键词：

allogeneic stem cell transplantation; graft versus tumor effect in brain; medulloblastoma; STEM-CELL TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; HER2-SPECIFIC T-CELLS; BONE-MARROW RESCUE; HIGH-RISK; REGRESSION; CANCER; BLOOD;

D O I：

10.1002/pbc.25525

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Marrow ablative chemotherapy (MAC) with autologous hematopoietic stem cell transplantation (HSCT) is limited by poor bone marrow reserve after chemotherapy and/or radiotherapy, and the extent of bone/bone marrow disease. We report a child with recurrent metastatic medulloblastoma who received an allogeneic HSCT while in relapse and subsequently achieved radiological resolution of disease and favorable marrow minimal residual disease (MRD) response. Disease recurred intra-cranially at 304 days post-HSCT. Tumor biopsy 488 days post-HSCT showed infiltration with donor lymphocytes demonstrating graft-versus-tumor (GVT) effect. The patient remained alive >2 years post-HSCT. Allogeneic HSCT may be a consideration for high-risk recurrent medulloblastoma. Pediatr Blood Cancer 2015;62:1667-1669. (c) 2015 Wiley Periodicals, Inc.

引用

页码：1667 / 1669

页数：3

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