Colorectal cancer. Genetic variants in BMP signaling pathway and ancestry in the Mexican population

被引：0

作者：

Haro-Santa-Cruz, Jorge ^{[1
]}

Colistro, Valentina ^{[2
]}

Cardenas-Cadena, Sergio ^{[3
]}

Luna-Perez, Pedro ^{[4
]}

Garcia-Gonzalez, Irma S. ^{[5
]}

Sans, Monica ^{[6
]}

Carracedo, Angel ^{[7
]}

Cruz, Raquel ^{[7
]}

Castelan-Maldonado, Edmundo ^{[4
]}

Murillo-Martinez, Carlos ^{[3
]}

Jaramillo-Rodriguez, Yolanda ^{[8
]}

Borrego-Soto, Gissela ^{[3
]}

Ruiz-Flores, Pablo ^{[1
]}

Ortiz-Lopez, Rocio ^{[3
]}

Rojas-Martinez, Augusto ^{[3
]}

机构：

[1] Univ Autonoma Coahuila, Fac Med, Saltillo, Coahuila, Mexico

[2] Univ Republica, Fac Med, Montevideo, Uruguay

[3] Univ Autonoma Nuevo Leon, Ctr Invest & Desarrollo Ciencias Salud, San Nicolas De Los Garza, Nuevo Leon, Mexico

[4] Hosp Oncol, Ctr Med Nacl Siglo 21, Inst Mexicano Seguro Social, Ciudad De Mexico, Mexico

[5] Inst Mexicano Seguro Social, Unidad Med Alta Especialidad 25, Torreon, Nuevo Leon, Mexico

[6] Univ Republica, Fac Humanidades & Ciencias Educ, Montevideo, Uruguay

[7] Univ Santiago de Compostela, Grp Med Xenom, Santiago De Compostela, Spain

[8] Inst Mexicano Seguro Social, Unidad Med Alta Especialidad 71, Coahuila, Mexico

来源：

GACETA MEDICA DE MEXICO | 2022年 / 158卷 / 06期

关键词：

Colorectal cancer; Association study; Mexico; Single-nucleotide polymorphisms; Bone morphogenetic proteins; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; RISK; IDENTIFICATION; SMAD7; METAANALYSIS;

D O I：

10.24875/GMM.22000185

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Genetic variants related to bone morphogenetic proteins (BMP2, BMP4, GREM1, SMAD7) signaling pathway have been associated with colorectal cancer, mainly in Caucasian populations. Objective: To describe the association of variants in members of the BMP signaling pathway in a Mexican population, characterized by its indigenous American and Caucasian ancestry. Methods: Genotyping of 1,000 colorectal cancer cases and 1,043 control individuals recruited in Mexico City, Monterrey, and Torreon was carried out using the Sequenom platform. Associations between colorectal cancer and variants were studied with univariate and multivariate analyses. Results: Variants rs4444235, rs12953717 and rs4939827 replicated the association with the neoplasm (p <= 0.05). Caucasian ancestry showed association with the tumor. Conclusions: The study replicated the associations between colorectal cancer and SMAD7 and BMP4 variants, with an association being observed with the Caucasian component of the ethnic mix.

引用

页码：419 / 424

页数：6

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