LTBP-2 acts as a novel marker in human heart failure - a preliminary study

被引：21
作者：
Bai, Yuanyuan [1 ,2 ]
Zhang, Peng [1 ,2 ]
Zhang, Xiaoling [1 ,2 ]
Huang, Jie [1 ,2 ]
Hu, Shengshou [1 ,2 ]
Wei, Yingjie [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China
[2] Chinese Acad Med Sci, Peking Union Med Coll, Fuwai Hosp, Beijing 100037, Peoples R China
来源：
BIOMARKERS | 2012年 / 17卷 / 05期
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
Latent TGF-beta binding protein 2 (LTBP-2); heart failure; heart failure with reduced ejection fraction; signaling pathway; biomarker; BETA-BINDING-PROTEIN; GENE-EXPRESSION; NT-PROBNP; DIAGNOSIS; FIBROSIS; CARDIOMYOCYTES; FIBRILLIN-1; CARDIOLOGY; PATHWAY; MMP-10;
D O I：
10.3109/1354750X.2012.677860
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: We have observed increased expression of latent TGF-beta binding protein (LTBP)-2 mRNA in human failing hearts. This study was aimed to further confirm LTBP-2 act as a novel marker in human acute heart failure. Methods and results: We demonstrated that median level of LTBP-2 in myocardial samples from heart failure patients was significantly elevated, and TGF-beta 1 significantly promoted LTBP-2 expression in neonatal rat cardiomyocytes. To investigate the potential of LTBP-2 as a biomarker to diagnose heart failure with reduced ejection fraction (HFREF), another cohort of 133 consecutive patients with dyspnea were enrolled. In receiver operating characteristic (ROC) curve analyses to detect HFREF, LTBP-2 achieved an area under curve (AUC) of 0.67 (95% confidence intervals (CI) 0.58-0.75), comparable to the diagnostic ability of NT-proBNP 0.68 (95% CI 0.59-0.77). Conclusion: The serum LTBP-2 levels might act as a promising biomarker in HFREF.
引用
收藏
页码：407 / 415
页数：9
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