Ghrelin and its interactions with growth hormone, leptin and orexins: Implications for the sleep-wake cycle and metabolism

被引:41
|
作者
Garcia-Garcia, Fabio [1 ,2 ]
Juarez-Aguilar, Enrique [2 ]
Santiago-Garcia, Juan [3 ]
Cardinali, Daniel P. [4 ]
机构
[1] Univ Veracruzana, Inst Ciencias Salud, Dept Biomed, Lab Biol & Sueno, Xalapa 91190, Veracruz, Mexico
[2] Univ Veracruzana, Inst Ciencias Salud, Dept Biomed, Xalapa 91190, Veracruz, Mexico
[3] Univ Veracruzana, Inst Invest Biol, Xalapa 91190, Veracruz, Mexico
[4] Pontificia Univ Catolica Argentina, Dept Docencia & Invest, Buenos Aires, DF, Argentina
关键词
Sleep-wake cycle; Ghrelin; Orexin; Growth hormone; Leptin; Obesity; SLOW-WAVE SLEEP; REM-SLEEP; BODY-WEIGHT; FOOD-INTAKE; BIOCHEMICAL REGULATION; NOCTURNAL GHRELIN; DIURNAL RHYTHM; DEFICIENT MICE; APNEA SYNDROME; PLASMA LEPTIN;
D O I
10.1016/j.smrv.2013.04.003
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Several studies have shown that ghrelin administration promotes wakefulness in rodents, while in human males it induces sleep but has no effect in women. Ghrelin also plays an important role in metabolism and appetite regulation, and as described in this review may participate in the energy balance during sleep. In this review, we summarize some of the effects induced by ghrelin administration on the sleep wake cycle in relation to the effects of other hormones, such as growth hormone, leptin, and orexin. Finally we discuss the relationship between sleep deprivation, obesity and ghrelin secretion pattern. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:89 / 97
页数:9
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