Gut-kidney kaliuretic signaling: looking forward to feeding

被引：12

作者：

Hoorn, Ewout J. ^{[1
]}

Zietse, Robert ^{[1
]}

机构：

[1] Erasmus MC, Dept Internal Med, Div Nephrol & Transplantat, NL-3000 CA Rotterdam, Netherlands

来源：

KIDNEY INTERNATIONAL | 2015年 / 88卷 / 06期

关键词：

BLOOD-PRESSURE; SODIUM; COTRANSPORTER; HYPOKALEMIA; NATRIURESIS; INHIBITION; CHLORIDE; NCC; K+;

D O I：

10.1038/ki.2015.272

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Preston et al. report urinary potassium excretion in healthy subjects in response to an acute potassium load with or without a meal. The investigators show a rapid kaliuretic response that occurs independently of the serum potassium and plasma aldosterone concentration, and that persists in the presence of a mineralocorticoid receptor blocker. This Commentary puts these data in perspective by reviewing the current understanding of the feedback and feedforward systems that regulate renal potassium excretion.

引用

页码：1230 / 1232

页数：4

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