Light-Operated Mechanized Nanoparticles

被引：430

作者：

Ferris, Daniel P. ^{[1
]}

Zhao, Yan-Li ^{[1
]}

Khashab, Niveen M. ^{[2
]}

Khatib, Hussam A. ^{[2
]}

Stoddart, J. Fraser ^{[1
,2
]}

Zink, Jeffrey I. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 05期

基金：

美国国家科学基金会;

关键词：

MESOPOROUS SILICA NANOPARTICLES; DRIVEN MOLECULAR SHUTTLE; DRUG-DELIVERY SYSTEM; GEL THIN-FILMS; INCLUSION COMPLEXES; BETA-CYCLODEXTRIN; SUPRAMOLECULAR NANOVALVE; LUMINESCENT MOLECULES; ALPHA-CYCLODEXTRIN; CONTROLLED-RELEASE;

D O I：

10.1021/ja807798g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mesoporous silica (MCM-41) nanoparticles modified by azobenzene derivatives, capable of storing small molecules and releasing them following light irradiation, have been fabricated and characterized. In the presence of the beta-cyclodextrin and/or pyrene-modified beta-cyclodextrin rings, the beta-cyclodextrin and/or pyrene-modified beta-cyclodextrin rings will thread onto the azobenzene-containing stalks and bind to trans-azobenzene units to form the pseudorotaxanes, thus seating the nanopores and stopping release of the cargo. Upon irradiation, the isomerization of trans-to-cis azobenzene units leads to the dissociation of the beta-cyclodextrin and/or pyrene-modified beta-cyclodextrin rings from the stalks, thus opening the gates to the nanopores and releasing the cargo.

引用

页码：1686 / +

页数：4

共 50 条

[41] Mesoporous silica nanoparticles for intracellular delivery of membrane-impermeable proteins
Slowing, Igor I.
Trewyn, Brian G.
Lin, Victor S. -Y.
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (28) : 8845 - 8849
[42] Mesoporous silica nanoparticles for drug delivery and biosensing applications
Slowing, Igor I.
Trewyn, Brian G.
Giri, Supratim
Lin, Victor S. -Y
[J]. ADVANCED FUNCTIONAL MATERIALS, 2007, 17 (08) : 1225 - 1236
[43] Stanier CA, 2002, ANGEW CHEM INT EDIT, V41, P1769, DOI 10.1002/1521-3773(20020517)41:10<1769::AID-ANIE1769>3.0.CO
[44] 2-N
[45] Femtosecond time-resolved spectroscopy of photoisomerization of methyl orange in cyclodextrins
Takei, M
Yui, H
Hirose, Y
Sawada, T
[J]. JOURNAL OF PHYSICAL CHEMISTRY A, 2001, 105 (51) : 11395 - 11399
[46] Contrast viscosity changes upon photoirradiation for mixtures of poly(acrylic acid)-based α-cyclodextrin and azobenzene polymers
Tomatsu, I
Hashidzume, A
Harada, A
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (07) : 2226 - 2227
[47] A new property of MCM-41:: Drug delivery system
Vallet-Regi, M
Rámila, A
del Real, RP
Pérez-Pariente, J
[J]. CHEMISTRY OF MATERIALS, 2001, 13 (02) : 308 - 311
[48] Mesoporous materials for drug delivery
Vallet-Regi, Maria
Balas, Francisco
Arcos, Daniel
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (40) : 7548 - 7558
[49] pH-responsive carrier system based on carboxylic acid modified mesoporous silica and polyelectrolyte for drug delivery
Yang, Q
Wang, SH
Fan, PW
Wang, LF
Di, Y
Lin, KF
Xiao, FS
[J]. CHEMISTRY OF MATERIALS, 2005, 17 (24) : 5999 - 6003
[50] STABILITY AND STRUCTURE OF THE INCLUSION COMPLEXES OF ALKYL-SUBSTITUTED HYDROXYPHENYLAZO DERIVATIVES OF SULFANILIC ACID WITH ALPHA-CYCLODEXTRIN AND BETA-CYCLODEXTRIN
YOSHIDA, N
SEIYAMA, A
FUJIMOTO, M
[J]. JOURNAL OF PHYSICAL CHEMISTRY, 1990, 94 (10) : 4254 - 4259

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