Circulating Metabolites and the Development of Type 2 Diabetes in Chinese Adults

被引：21

作者：

Bragg, Fiona ^{[1
,2
]}

Kartsonaki, Christiana ^{[1
,2
]}

Guo, Yu ^{[3
]}

Holmes, Michael ^{[1
,2
]}

Du, Huaidong ^{[1
,2
]}

Yu, Canqing ^{[4
,5
]}

Pei, Pei ^{[6
]}

Yang, Ling ^{[1
,2
]}

Jin, Donghui ^{[7
]}

Chen, Yiping ^{[1
,2
]}

Schmidt, Dan ^{[1
]}

Avery, Daniel ^{[1
]}

Lv, Jun ^{[4
,5
]}

Chen, Junshi ^{[8
]}

Clarke, Robert ^{[1
,2
]}

Hill, Michael ^{[1
]}

Li, Liming ^{[4
,5
]}

Millwood, Iona ^{[1
,2
]}

Chen, Zhengming ^{[1
,2
]}

机构：

[1] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit & Epidemiol Studies Unit CTSU, Oxford, England

[2] Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford, England

[3] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, Beijing, Peoples R China

[4] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hlth Sci Ctr, Beijing, Peoples R China

[5] Peking Univ, Ctr Publ Hlth & Epidem Preparedness & Response, Beijing, Peoples R China

[6] Chinese Acad Med Sci, Beijing, Peoples R China

[7] Hunan Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R China

[8] China Natl Ctr Food Safety Risk Assessment, Beijing, Peoples R China

来源：

DIABETES CARE | 2022年 / 45卷 / 02期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

INSULIN-RESISTANCE; METABOLOMICS; RISK; DISEASE;

D O I：

10.2337/dc21-1415

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE To assess prospective associations of circulating metabolites with the risk of type 2 diabetes (T2D) among Chinese adults. RESEARCH DESIGN AND METHODS A case-cohort study within the 8-year prospective China Kadoorie Biobank comprised 882 participants with incident T2D and 789 subcohort participants. Nuclear magnetic resonance metabolomic profiling quantified 225 metabolites in stored baseline plasma samples. Cox regression related individual metabolites with T2D risk, adjusting for potential confounders and fasting time. RESULTS After correction for multiple testing, 163 metabolites were significantly associated with the risk of T2D (P < 0.05). There were strong positive associations of VLDL particle size, the ratio of apolipoprotein B to apolipoprotein A-1, branched-chain amino acids, glucose, and triglycerides with T2D, and inverse associations of HDL-cholesterol, HDL particle size, and relative n-3 and saturated fatty acid concentrations. CONCLUSIONS In Chinese adults, metabolites across diverse pathways were independently associated with T2D risk, providing valuable etiological insights and potential to improve T2D risk prediction.

引用

页码：477 / 480

页数：4

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