Exploration of Wedelia chinensis leaf-assisted silver nanoparticles for antioxidant, antibacterial and in vitro cytotoxic applications

被引:34
作者
Das, Merina Paul [1 ]
Livingstone, Jeyanthi Rebecca [1 ]
Veluswamy, Pandiyarasan [2 ]
Das, Jayabrata [3 ]
机构
[1] Bharath Univ, Dept Ind Biotechnol, Madras 600073, Tamil Nadu, India
[2] Shizuoka Univ, Dept Elect & Mat Sci, Elect Res Inst, Hamamatsu, Shizuoka 4328011, Japan
[3] SRM Univ, Dept Biotechnol, Sch Bioengn, Madras 603203, Tamil Nadu, India
关键词
Wedelia chinensis; AgNPs; Antioxidant; Antibacterial; Cytotoxicity; GREEN SYNTHESIS; GOLD NANOPARTICLES; CELL LINES; AG-NPS; EXTRACT; BIOSYNTHESIS; PARTICLES; BREAST; GROWTH; MCF-7;
D O I
10.1016/j.jfda.2017.07.014
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Green synthetic route of silver nanoparticles (AgNPs) has already been proved to be an advantageous over other physico-chemical approaches due to its simplicity, cost effectiveness, ecofriendly and nontoxicity. In this finding, aqueous Wedelia chinensis leaf extract (WLE) mediated synthesis of AgNPs was approached. Surface plasmon resonance (SPR) band at 408 nm preliminary indicated the formation of AgNPs, while TEM and XRD characterization confirmed the formation of spherically shaped and crystalline AgNPs with an average size of 31.68 nm, respectively. The plausible biomolecules in the aqueous leaf extract responsible for the reduction and stabilization of AgNPs were identified by FTIR analysis and found to be polyphenolic groups in flavonoid. Further, synthesized AgNPs was explored for different biological applications. Biosynthesized AgNPs showed significant free radical scavenging activity as compared to Wedelia leaf extract and antibacterial activity against clinically isolated test pathogens where Gram-negative bacteria were found more susceptible to AgNPs than Gram-positive one. In addition, in vitro cytotoxic response was also evaluated on hepatocellular carcinoma Hep G2 cell lines and showed a dose dependent cytotoxic response with an ICso value of 25 mu g/mL. Copyright (C) 2017, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码:917 / 925
页数:9
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