Rh(III)-Catalyzed Redox-Neutral Cascade Annulation of Benzamides withp-Quinone Methides

被引：16

作者：

Kanchupalli, Vinaykumar ^{[1
]}

Shukla, Rahul K. ^{[1
]}

Singh, Anurag ^{[1
]}

Volla, Chandra M. R. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 29期

关键词：

C-H activation; Rh-catalysis; Cascade reactions; Redox-neutral; Isoquinolinones; C-H ACTIVATION; ASYMMETRIC 1,6-CONJUGATE ADDITION; EXPEDIENT ACCESS; BOND FORMATION; FUNCTIONALIZATION; CYCLIZATION; CATALYST; CONSTRUCTION; 1,6-ADDITION; STRATEGY;

D O I：

10.1002/ejoc.202000863

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we demonstrate a [RhCp*Cl-2](2)catalyzed synthesis of isoindolo[2,1-b]isoquinolin-5(7H)-one derivatives fromN-(pivaloyloxy)benzamides andp-quinone methides under redox neutral conditions.p-Quinone methide derivatives were engaged for the first time as precursors in C-H activation reactions and the cascade sequence consists of Rh(III)-catalyzed C-H activation, alkyne insertion followed by an intramolecular 1,6-conjugate addition. This novel tandem reaction strategy offers a rapid and straightforward access to complex fused isoquinolinone derivatives in an efficient manner.

引用

页码：4494 / 4498

页数：5

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