Rh(III)-Catalyzed Redox-Neutral Cascade Annulation of Benzamides withp-Quinone Methides

被引：16
|
作者：
Kanchupalli, Vinaykumar [1 ]
Shukla, Rahul K. [1 ]
Singh, Anurag [1 ]
Volla, Chandra M. R. [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 29期
关键词：
C-H activation; Rh-catalysis; Cascade reactions; Redox-neutral; Isoquinolinones; C-H ACTIVATION; ASYMMETRIC 1,6-CONJUGATE ADDITION; EXPEDIENT ACCESS; BOND FORMATION; FUNCTIONALIZATION; CYCLIZATION; CATALYST; CONSTRUCTION; 1,6-ADDITION; STRATEGY;
D O I：
10.1002/ejoc.202000863
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we demonstrate a [RhCp*Cl-2](2)catalyzed synthesis of isoindolo[2,1-b]isoquinolin-5(7H)-one derivatives fromN-(pivaloyloxy)benzamides andp-quinone methides under redox neutral conditions.p-Quinone methide derivatives were engaged for the first time as precursors in C-H activation reactions and the cascade sequence consists of Rh(III)-catalyzed C-H activation, alkyne insertion followed by an intramolecular 1,6-conjugate addition. This novel tandem reaction strategy offers a rapid and straightforward access to complex fused isoquinolinone derivatives in an efficient manner.
引用
收藏
页码：4494 / 4498
页数：5
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