CD28-induced cytokine production and proliferation by thymocytes are differentially regulated by the p59(fyn) tyrosine kinase

被引:0
|
作者
Ong, CJ [1 ]
Lim, ASP [1 ]
Teh, HS [1 ]
机构
[1] UNIV BRITISH COLUMBIA,DEPT IMMUNOL & MICROBIOL,VANCOUVER,BC V6T 1Z3,CANADA
来源
JOURNAL OF IMMUNOLOGY | 1997年 / 159卷 / 05期
关键词
T-CELL ACTIVATION; ACCESSORY MOLECULE CD28; PHOSPHATIDYLINOSITOL; 3-KINASE; INTERLEUKIN-2; PRODUCTION; COUNTER-RECEPTOR; LYMPHOCYTES-T; MESSENGER-RNA; B-CELLS; ANTIGEN; CTLA-4;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD28 is a 44-kDa homodimeric receptor that is expressed on the majority of T cells, Engagement of the CD28 receptor by soluble anti-CD28 mAb in conjunction with phorbol ester (PMA) induces the production of cytokines and the proliferation of resting T cells via signal transduction pathways independent of the TCR. Evidence is provided herein that CD28 signals leading to cytokine production do not require the p59(fyn) (Fyn) tyrosine kinase, whereas CD28-mediated proliferation is dependent on the presence of the Fyn kinase in thymic, but not lymph node, cells, The defect in proliferation is not due to failure of IL-2R signaling, since addition of high concentrations of exogenous IL-2 can overcome the proliferative defect, Analysis of CD28-directed induction of the IL-2R alpha (CD25)-chain, which confers high affinity binding to IL-2, showed that Fyn-deficient thymocytes, but not lymph node cells, failed to up-regulate CD25 expression following anti-CD28 and PMA stimulation. Thus, the Fyn tyrosine kinase is critically required for thymic CD28-mediated CD25 expression and proliferation but not for CD28-mediated cytokine production.
引用
收藏
页码:2169 / 2176
页数:8
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