Zebrafish semaphorin Z1b inhibits growing motor axons in vivo

被引：46

作者：

Roos, M

Schachner, M

Bernhardt, RR

机构：

[1] Univ Hamburg, Zentrum Mol Neurobiol Hamburg, D-20246 Hamburg, Germany

[2] Swiss Fed Inst Technol, Dept Neurobiol, CH-8093 Zurich, Switzerland

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 87卷 / 1-2期

关键词：

embryo; somites; rhombomeres; recognition molecules; collapsin; semaphorin; axon guidance; repulsion; motor axon; overexpression;

D O I：

10.1016/S0925-4773(99)00153-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Zebrafish semaphorin Ib (sema Zlb) is a new member of the semaphorin family, related to mammalian sema Drm. It is expressed in rhombomeres three and five, and in the posterior half of newly formed somites which is avoided by ventrally extending motor axone. Embryos injected at the 1-2 cell stage with synthetic sema Zlb mRNA developed normally but many (63%) showed missing or stunted ventral motor nerves. Other axons, somites, and hindbrain rhombomeres were not affected. No abnormalities were seen in control embryos injected with lacZ mRNA. Sema Zlb might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：103 / 117

页数：15

共 83 条

[1] A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis [J].