A model for fast predicting and optimizing the sensitivity of surface-relief guided mode resonance sensors

被引：29

作者：

Lin, Sheng Fu ^{[1
]}

Wang, Chih Ming ^{[2
]}

Tsai, Ya Lun ^{[1
]}

Ding, Ting Jou ^{[1
]}

Yang, Tsung Hsun ^{[1
]}

Chen, Wen Yih ^{[3
]}

Yeh, Song Feng ^{[4
]}

Chang, Jenq Yang ^{[1
,5
]}

机构：

[1] Natl Cent Univ, Dept Opt & Photon, Jhongli 32001, Taiwan

[2] Natl Dong Hwa Univ, Dept Optoelect Engn, Hualien 97401, Taiwan

[3] Natl Cent Univ, Dept Chem & Mat Engn, Jhongli 32001, Taiwan

[4] Taiwan Landseed Hosp, Dept Internal Med, Div Rheumatol Immunol Allergy, Tao Yuan 32449, Taiwan

[5] Natl Cent Univ, Ctr Opt, Jhongli 32001, Taiwan

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2013年 / 176卷

关键词：

Optical biosensors; Guided mode resonance device; Bulk sensitivity; Waveguide;

D O I：

10.1016/j.snb.2012.02.014

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A modified waveguide model for predicting the sensitivity of surface-relief guided mode resonance (GMR) biosensors is presented. The proposed model is a convenient and fast calculation method compared to the current optical simulation tools such as the rigorous couple wave analysis (RCWA). A systematic and theoretical discussion of the GMR geometric structure and sensitivity of the modified model for biosensing is also presented. For a given GMR material, the theoretical maximum sensitivity can be achieved by choosing the proper geometric structure from the model simulations. A comparison of the GMR biosensor sensitivity respectively calculated by the model and the RCWA method shows good agreement. Finally, a suspending GMR structure with a 4.5-fold increase in sensitivity compared to the traditional surface-relief GMR is proposed. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1197 / 1203

页数：7

共 21 条

[1] Use of optical biosensor technology to study immunological cross-reactivity between different sulfonamide drugs [J].

Ahmad, A ;

Ramakrishnan, A ;

McLean, MA ;

Li, DB ;

Rock, MT ;

Karim, A ;

Breau, AP .

ANALYTICAL BIOCHEMISTRY, 2002, 300 (02) :177-184

[2] Sensitivity model for predicting photonic crystal biosensor performance [J].

Block, Ian D. ;

Ganesh, Nikhil ;

Lu, Meng ;

Cunningham, Brian T. .

IEEE SENSORS JOURNAL, 2008, 8 (3-4) :274-280

[3] Photonic crystal optical biosensor incorporating structured low-index porous dielectric [J].

Block, Ian D. ;

Chan, Leo L. ;

Cunningham, Brian T. .

SENSORS AND ACTUATORS B-CHEMICAL, 2006, 120 (01) :187-193

[4] Label-free assays on the BIND system [J].

Cunningham, BT ;

Li, P ;

Schulz, S ;

Lin, B ;

Baird, C ;

Gerstenmaier, J ;

Genick, C ;

Wang, F ;

Fine, E ;

Laing, L .

JOURNAL OF BIOMOLECULAR SCREENING, 2004, 9 (06) :481-490

[5] Determination of the refractive index increments of small molecules for correction of surface plasmon resonance data [J].

Davis, TM ;

Wilson, WD .

ANALYTICAL BIOCHEMISTRY, 2000, 284 (02) :348-353

[6] Silicon-on-Insulator microring resonator for sensitive and label-free biosensing [J].

De Vos, Katrien ;

Bartolozzi, Irene ;

Schacht, Etienne ;

Bienstman, Peter ;

Baets, Roel .

OPTICS EXPRESS, 2007, 15 (12) :7610-7615

[7] Fabrication of a graded-wavelength guided-mode resonance filter photonic crystal [J].

Dobbs, Dennis W. ;

Gershkovich, Irena ;

Cunningham, Brian T. .

APPLIED PHYSICS LETTERS, 2006, 89 (12)

[8] Sensitivity enhancement in photonic crystal slab biosensors [J].

El Beheiry, Mohamed ;

Liu, Victor ;

Fan, Shanhui ;

Levi, Ofer .

OPTICS EXPRESS, 2010, 18 (22) :22702-22714

[9] Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer [J].

El-Sayed, IH ;

Huang, XH ;

El-Sayed, MA .

NANO LETTERS, 2005, 5 (05) :829-834

[10] Present and future of surface plasmon resonance biosensors [J].

Homola, J .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2003, 377 (03) :528-539

← 1 2 3 →