Stem cell-derived exosomal transcriptomes for wound healing

被引：7
作者：
Chen, Guiling [1 ,2 ,3 ,4 ]
Chen, Hankun [5 ]
Zeng, Xiang [1 ,2 ,3 ,4 ]
Zhu, Wei [1 ,2 ,4 ]
机构：
[1] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Peoples R China
[2] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China
[3] Guangdong Prov Hosp Chinese Med, Natl Inst Stem Cell Clin Res, Guangzhou, Peoples R China
[4] Guangdong Prov Acad Chinese Med Sci, Guangzhou, Peoples R China
[5] Guangzhou Qinglan Biotechnol Co Ltd, Res & Dev Dept, Guangzhou, Peoples R China
来源：
FRONTIERS IN SURGERY | 2022年 / 9卷
关键词：
wound healing; stem cell; exosome; microRNA; long noncoding RNA; circular RNA; messenger RNA; MESSENGER-RNAS; ENDOTHELIAL-CELLS; CIRCULAR RNA; MIRNAS; ANGIOGENESIS; MECHANISMS; MICRORNAS; PROLIFERATION; MIGRATION; APOPTOSIS;
D O I：
10.3389/fsurg.2022.933781
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Wound healing is a complex and integrated process of the interaction of various components within the injured tissue. Accumulating evidence suggested that stem cell-derived exosomal transcriptomes could serve as key regulatory molecules in wound healing in stem cell therapy. Stem cell-derived exosomal transcriptomes mainly consist of long noncoding RNAs (lncRNAs), microRNAs (miRNAs), circular RNAs (circRNAs) and messenger RNAs (mRNAs). In this article we presented a brief introduction on the wound repair process and exosomal transcriptomes. Meanwhile, we summarized our current knowledge of the involvement of exosomal transcriptomes in physiological and pathological wound repair process including inflammation, angiogenesis, and scar formation.
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页数：12
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