Stem cell-derived exosomal transcriptomes for wound healing

被引：7
|
作者：
Chen, Guiling [1 ,2 ,3 ,4 ]
Chen, Hankun [5 ]
Zeng, Xiang [1 ,2 ,3 ,4 ]
Zhu, Wei [1 ,2 ,4 ]
机构：
[1] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Peoples R China
[2] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China
[3] Guangdong Prov Hosp Chinese Med, Natl Inst Stem Cell Clin Res, Guangzhou, Peoples R China
[4] Guangdong Prov Acad Chinese Med Sci, Guangzhou, Peoples R China
[5] Guangzhou Qinglan Biotechnol Co Ltd, Res & Dev Dept, Guangzhou, Peoples R China
来源：
FRONTIERS IN SURGERY | 2022年 / 9卷
关键词：
wound healing; stem cell; exosome; microRNA; long noncoding RNA; circular RNA; messenger RNA; MESSENGER-RNAS; ENDOTHELIAL-CELLS; CIRCULAR RNA; MIRNAS; ANGIOGENESIS; MECHANISMS; MICRORNAS; PROLIFERATION; MIGRATION; APOPTOSIS;
D O I：
10.3389/fsurg.2022.933781
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Wound healing is a complex and integrated process of the interaction of various components within the injured tissue. Accumulating evidence suggested that stem cell-derived exosomal transcriptomes could serve as key regulatory molecules in wound healing in stem cell therapy. Stem cell-derived exosomal transcriptomes mainly consist of long noncoding RNAs (lncRNAs), microRNAs (miRNAs), circular RNAs (circRNAs) and messenger RNAs (mRNAs). In this article we presented a brief introduction on the wound repair process and exosomal transcriptomes. Meanwhile, we summarized our current knowledge of the involvement of exosomal transcriptomes in physiological and pathological wound repair process including inflammation, angiogenesis, and scar formation.
引用
收藏
页数：12
相关论文
共 50 条
  • [1] Exosomal microRNAs from Mesenchymal Stem Cells: Novel Therapeutic Effect in Wound Healing
    Ju, Congcong
    Liu, Dewu
    TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2023, 20 (05) : 647 - 660
  • [2] Combination Therapy of Stem Cell-derived Exosomes and Biomaterials in the Wound Healing
    Golchin, Ali
    Shams, Forough
    Basiri, Arefeh
    Ranjbarvan, Parviz
    Kiani, Samaneh
    Sarkhosh-Inanlou, Roya
    Ardeshirylajimi, Abdolreza
    Aziz, Shiva Gholizadeh-Ghaleh
    Sadigh, Sanaz
    Rasmi, Yousef
    STEM CELL REVIEWS AND REPORTS, 2022, 18 (06) : 1892 - 1911
  • [3] Combination Therapy of Stem Cell-derived Exosomes and Biomaterials in the Wound Healing
    Ali Golchin
    Forough Shams
    Arefeh Basiri
    Parviz Ranjbarvan
    Samaneh Kiani
    Roya Sarkhosh-Inanlou
    Abdolreza Ardeshirylajimi
    Shiva Gholizadeh-Ghaleh Aziz
    Sanaz Sadigh
    Yousef Rasmi
    Stem Cell Reviews and Reports, 2022, 18 : 1892 - 1911
  • [4] The Mechanisms of Adipose Stem Cell-Derived Exosomes Promote Wound Healing and Regeneration
    Lin, Zhengjie
    Lin, Danyi
    Lin, Dane
    AESTHETIC PLASTIC SURGERY, 2024, 48 (14) : 2730 - 2737
  • [5] Exosome derived from stem cell: A promising therapeutics for wound healing
    Lv, Hui
    Liu, Hanxiao
    Sun, Ting
    Wang, Han
    Zhang, Xiao
    Xu, Wei
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [6] Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing
    Zhou, Chuchao
    Zhang, Boyu
    Yang, Yanqing
    Jiang, Qiong
    Li, Tianyu
    Gong, Jun
    Tang, Hongbo
    Zhang, Qi
    STEM CELL RESEARCH & THERAPY, 2023, 14 (01)
  • [7] Therapeutic potential of exosomal lncRNAs derived from stem cells in wound healing: focusing on mesenchymal stem cells
    Morabbi, Ali
    Karimian, Mohammad
    STEM CELL RESEARCH & THERAPY, 2025, 16 (01)
  • [8] Acceleration of Wound Healing with Stem Cell-Derived Growth Factors
    Tamari, Masayuki
    Nishino, Yudai
    Yamamoto, Noriyuki
    Ueda, Minoru
    INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 2013, 28 (06) : E369 - E375
  • [9] Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomal MicroRNAs Suppress Myofibroblast Differentiation by Inhibiting the Transforming Growth Factor-β/SMAD2 Pathway During Wound Healing
    Fang, Shuo
    Xu, Chen
    Zhang, Yuntong
    Xue, Chunyu
    Yang, Chao
    Bi, Hongda
    Qian, Xijing
    Wu, Minjuan
    Ji, Kaihong
    Zhao, Yunpeng
    Wang, Yue
    Liu, Houqi
    Xing, Xin
    STEM CELLS TRANSLATIONAL MEDICINE, 2016, 5 (10) : 1425 - 1439
  • [10] Stem Cell-Derived Exosomes and Nanovesicles: Promotion of Cell Proliferation, Migration, and Anti-Senescence for Treatment of Wound Damage and Skin Ageing
    Cha, Hyeonjin
    Hong, Seyoung
    Park, Ju Hyun
    Park, Hee Ho
    PHARMACEUTICS, 2020, 12 (12) : 1 - 18
12345