Effect of A1 adenosine receptor agonist upon cochlear dysfunction induced by transient ischemia

被引：11

作者：

Tabuchi, K ^{[1
]}

Ito, Z ^{[1
]}

Wada, T ^{[1
]}

Takahashi, K ^{[1
]}

Hara, A ^{[1
]}

Kusakari, J ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Clin Med, Dept Otolaryngol, Tsukuba, Ibaraki 3058575, Japan

来源：

HEARING RESEARCH | 1999年 / 136卷 / 1-2期

关键词：

cochlea; compound action potential (CAP); transient ischemia; 2-chloro-N6-cyclopentyladenosine (CCPA); A1 adenosine receptor;

D O I：

10.1016/S0378-5955(99)00111-2

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

The present study was undertaken to determine whether 2-chloro-N6-cyclopentyladenosine (CCPA), a highly selective Al adenosine receptor agonist, attenuated cochlear dysfunction induced by transient ischemia or not. Ischemia of different durations (15, 30 or 60 min) was induced in 46 albino guinea pigs by transiently pressing the labyrinthine artery. CCPA or physiological saline solution was intraperitoneally administered to the animals 15 min prior to ischemia. The post-ischemic CAP threshold shift from the pre-administration value was measured 4 h after the onset of reperfusion to assess post-ischemic cochlear dysfunction. A statistically significant reduction in the CAP threshold shift was seen in CCPA-given animals after 15- and 30-min ischemia, whereas there was no statistical difference after 60-min ischemia. These results suggest that Al adenosine receptor agonist exerts a protective effect on the cochlear injury induced by transient ischemia of intermediate duration. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：86 / 90

页数：5

共 17 条

[1] The effect of mannitol upon cochlear dysfunction induced by transient local anoxia
Tabuchi, K
Ito, Z
Wada, T
Hara, A
Kusakari, J
HEARING RESEARCH, 1998, 126 (1-2) : 28 - 36
[2] Effect of 7-nitroindazole upon cochlear dysfunction induced by transient local anoxia
Tabuchi, K
Takahashi, K
Ito, Z
Hara, A
Wada, T
Kusakari, J
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2000, 109 (08): : 715 - 719
[3] Effect of ketamine, dextromethorphan, and MK-801 on cochlear dysfunction induced by transient ischemia
Tabuchi, K
Tsuji, S
Wada, T
Ito, Z
Hara, A
Kusakari, J
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2002, 111 (01): : 44 - 49
[4] The contribution of phospholipase A2 to the cochlear dysfunction induced by transient ischemia
Tabuchi, K
Ito, Z
Tsuji, S
Wada, T
Takahashi, K
Hara, A
Kusakari, J
HEARING RESEARCH, 2000, 144 (1-2) : 1 - 7
[5] Poly(adenosine diphosphate-ribose) synthetase inhibitor 3-aminobenzamide alleviates cochlear dysfunction induced by transient ischemia
Tabuchi, K
Ito, Z
Tsuji, S
Nakagawa, A
Serizawa, F
Hara, A
Kusakari, J
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2001, 110 (02): : 118 - 121
[6] Long-term observations on the reversibility of cochlear dysfunction after transient ischemia
Tsuji, S
Tabuchi, K
Hara, A
Kusakari, J
HEARING RESEARCH, 2002, 166 (1-2) : 72 - 81
[7] Prednisolone prevents transient ischemia-induced cochlear damage in gerbils
Maetani, Toshiki
Hyodo, Jun
Takeda, Shoichiro
Hakuba, Nobuhiro
Kiyofumi, Gyo
ACTA OTO-LARYNGOLOGICA, 2009, 129 : 24 - 27
[8] Noise induces A1 adenosine receptor expression in the chinchilla cochlea
Ramkumar, V
Whitworth, CA
Pingle, SC
Hughes, LF
Rybak, LP
HEARING RESEARCH, 2004, 188 (1-2) : 47 - 56
[9] Post exposure administration of A1 adenosine receptor agonists attenuates noise-induced hearing loss
Wong, Ann Chi Yan
Guo, Cindy X.
Gupta, Rita
Housley, Gary D.
Thorne, Peter R.
Vlajkovic, Srdjan M.
HEARING RESEARCH, 2010, 260 (1-2) : 81 - 88
[10] The effects of A1 and A2A adenosine receptor agonists on kainic acid excitotoxicity in the guinea pig cochlea
Tabuchi, Keiji
Sakai, Shuhei
Nakayama, Masahiro
Nishimura, Bungo
Hayashi, Kentaro
Hirose, Yuki
Hara, Akira
NEUROSCIENCE LETTERS, 2012, 518 (01) : 60 - 63

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