Is it time to re-evaluate our use of acetaminophen in certain sub-groups of pregnant women?

被引：6

作者：

Zelop, Carolyn M. ^{[1
]}

机构：

[1] St Francis Hosp & Med Ctr, Hartford, CT 06105 USA

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2008年 / 21卷 / 11期

关键词：

Pre-eclampsia; acetaminophen; pregnnacy complications;

D O I：

10.1080/14767050802379056

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

New insight into the pharmacological mechanisms of acetaminophen raises questions about its possible safety in certain subgroups of pregnant women. Recent focus on acetaminophen's ability to modulate prostaglandin synthesis may require modification of its ubiquitous use in pregnancy. Further basic science, epidemiologic and clinical studies are required to explore the interaction of acetaminophen with placentation leading to vascular pathologic conditions during pregnancy.

引用

页码：761 / 762

页数：2

共 6 条

[1] New insights into the mechanism of action of acetaminophen:: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases [J].