miRNAs in development and pathogenesis of the nervous system

被引：82

作者：

Nowak, Jakub S. ^{[1
]}

Michlewski, Gracjan ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2013年 / 41卷

基金：

英国医学研究理事会;

关键词：

microRNA (miRNA); microRNA biogenesis; nervous system; neuropathogenesis; synaptic plasticity; MICRORNA BIOGENESIS; LET-7; MICRORNA; SELF-RENEWAL; EXPRESSION; RNA; DISEASE; REST; DIFFERENTIATION; SPECIFICATION; NEUROGENESIS;

D O I：

10.1042/BST20130044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human nervous system expresses approximately 70% of all miRNAs (microRNAs). Changing levels of certain ubiquitous and brain-specific miRNAs shape the development and function of the nervous system. It is becoming clear that misexpression of some miRNAs can contribute towards neurodevelopmental disorders. In the present article, we review the current knowledge of the role of miRNAs in development and pathogenesis of the nervous system.

引用

页码：815 / 820

页数：6

共 49 条

[1] MicroRNAs and developmental timing
Ambros, Victor
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2011, 21 (04) : 511 - 517
[2] Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, RE
Van den Veyver, IB
Wan, M
Tran, CQ
Francke, U
Zoghbi, HY
[J]. NATURE GENETICS, 1999, 23 (02) : 185 - 188
[3] Dysregulation of miRNA 181b in the temporal cortex in schizophrenia
Beveridge, Natalie J.
Tooney, Paul A.
Carroll, Adam P.
Gardiner, Erin
Bowden, Nikola
Scott, Rodney J.
Tran, Nham
Dedova, Irina
Cairns, Murray J.
[J]. HUMAN MOLECULAR GENETICS, 2008, 17 (08) : 1156 - 1168
[4] Cao XW, 2006, ANNU REV NEUROSCI, V29, P77, DOI 10.1146/annurev.neuro.29.051605.112839
[5] Small regulatory RNAs in neurodevelopmental disorders
Chang, Shuang
Wen, Shengmei
Chen, Dahua
Jin, Peng
[J]. HUMAN MOLECULAR GENETICS, 2009, 18 : R18 - R26
[6] Terminal loop-mediated control of microRNA biogenesis
Choudhury, Nila Roy
Michlewski, Gracjan
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2012, 40 : 789 - 793
[7] Reciprocal actions of REST and a microRNA promote neuronal identity
Conaco, C
Otto, S
Han, JJ
Mandel, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (07) : 2422 - 2427
[8] NMDA receptor subunits: diversity, development and disease
Cull-Candy, S
Brickley, S
Farrant, M
[J]. CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (03) : 327 - 335
[9] A new role for microRNA-9 in human neural progenitor cells
Delaloy, Celine
Gao, Fen-Biao
[J]. CELL CYCLE, 2010, 9 (15) : 2913 - 2914
[10] Messenger-RNA-binding proteins and the messages they carry
Dreyfuss, G
Kim, VN
Kataoka, N
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (03) : 195 - 205

← 1 2 3 4 5 →