A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals

被引：0
作者：
Yan, XJ
Xin, L
Bin, W
Xue, ZZ
Yong, QT [1 ]
机构：
[1] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China
[2] Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
TETRAHEDRON | 2002年 / 58卷 / 09期
关键词：
spiroketal moiety; HIV-1; protease; intramolecular chiral induction;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The stereoselective synthesis of the spiroketal fragment 4a and its C1"-epimer 4b of the HIV-1 protease inhibitors didemnaketals has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective construction of four chiral carbon centers by intramolecular chiral induction. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1697 / 1708
页数：12
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