Particulate matter beyond mass: recent health evidence on the role of fractions, chemical constituents and sources of emission

被引:378
作者
Cassee, Flemming R. [1 ,2 ]
Heroux, Marie-Eve [3 ]
Gerlofs-Nijland, Miriam E. [1 ]
Kelly, Frank J. [4 ]
机构
[1] Natl Inst Publ Hlth & Environm, Dept Environm Hlth, NL-3720 BA Bilthoven, Netherlands
[2] Univ Utrecht, Inst Risk Assessment Studies, Utrecht, Netherlands
[3] WHO, European Ctr Environm & Hlth, Bonn, Germany
[4] Kings Coll London, MRC PHE Ctr Environm & Hlth, London, England
关键词
Air pollution - adverse effects; particulate matter; toxicology; STIMULATING-HORMONE LEVELS; DIESEL-EXHAUST INHALATION; TRAFFIC AIR-POLLUTION; PARTICLE-SIZE; INFLAMMATORY RESPONSES; COMBUSTION EMISSIONS; VASCULAR FUNCTION; OXIDATIVE STRESS; CHRONIC EXPOSURE; FINE PARTICLES;
D O I
10.3109/08958378.2013.850127
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Particulate matter (PM) is regulated in various parts of the world based on specific size cut offs, often expressed as 10 or 2.5 mu m mass median aerodynamic diameter. This pollutant is deemed one of the most dangerous to health and moreover, problems persist with high ambient concentrations. Continuing pressure to re-evaluate ambient air quality standards stems from research that not only has identified effects at low levels of PM but which also has revealed that reductions in certain components, sources and size fractions may best protect public health. Considerable amount of published information have emerged from toxicological research in recent years. Accumulating evidence has identified additional air quality metrics (e. g. black carbon, secondary organic and inorganic aerosols) that may be valuable in evaluating the health risks of, for example, primary combustion particles from traffic emissions, which are not fully taken into account with PM2.5 mass. Most of the evidence accumulated so far is for an adverse effect on health of carbonaceous material from traffic. Traffic-generated dust, including road, brake and tire wear, also contribute to the adverse effects on health. Exposure durations from a few minutes up to a year have been linked with adverse effects. The new evidence collected supports the scientific conclusions of the World Health Organization Air Quality Guidelines and also provides scientific arguments for taking decisive actions to improve air quality and reduce the global burden of disease associated with air pollution.
引用
收藏
页码:802 / 812
页数:11
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