Clustering of Rac1: Selective Lipid Sorting Drives Signaling

被引：7

作者：

Maxwell, Kelsey N. ^{[1
]}

Zhou, Yong ^{[1
]}

Hancock, John F. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Dept Integrat Biol & Pharmacol, McGovern Med Sch, Houston, TX 77030 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2018年 / 43卷 / 02期

关键词：

MEMBRANE; GTPASE;

D O I：

10.1016/j.tibs.2017.11.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of lipid-anchored small GTPases to form nanometer-scale lipid domains on the cell plasma membrane (PM) is precipitating exciting new insights into membrane-anchored protein regulation. A recent article by Remorino et al. demonstrates that Rac1, similar to Ras, forms nanoclusters on the PM. The implications of these findings are discussed herein.

引用

页码：75 / 77

页数：3

共 9 条

[1] Single-molecule tracking of small GTPase Rac1 uncovers spatial regulation of membrane translocation and mechanism for polarized signaling
Das, Sulagna
Yin, Taofei
Yang, Qingfen
Zhang, Jingqiao
Wu, Yi I.
Yu, Ji
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (03) : E267 - E276
[2] The T cell receptor resides in ordered plasma membrane nanodomains that aggregate upon patching of the receptor
Dinic, Jelena
Riehl, Astrid
Adler, Jeremy
Parmryd, Ingela
[J]. SCIENTIFIC REPORTS, 2015, 5
[3] The Rac GTPase in Cancer: From Old Concepts to New Paradigms
Kazanietz, Marcelo G.
Caloca, Maria J.
[J]. CANCER RESEARCH, 2017, 77 (20) : 5445 - 5451
[4] Lam B Daniel, 2013, Small GTPases, V4, P78, DOI 10.4161/sgtp.23310
[5] Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling
Remorino, Amanda
De Beco, Simon
Cayrac, Fanny
Di Federico, Fahima
Cornilleau, Gaetan
Gautreau, Alexis
Parrini, Maria Carla
Masson, Jean-Baptiste
Dahan, Maxime
Coppey, Mathieu
[J]. CELL REPORTS, 2017, 21 (07): : 1922 - 1935
[6] THE SMALL GTP-BINDING PROTEIN RAC REGULATES GROWTH-FACTOR INDUCED MEMBRANE RUFFLING
RIDLEY, AJ
PATERSON, HF
JOHNSTON, CL
DIEKMANN, D
HALL, A
[J]. CELL, 1992, 70 (03) : 401 - 410
[7] Dissociation of Rac1(GDP)•RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, rac guanine nucleotide exchange factor, and GTP
Ugolev, Yelena
Berdichevsky, Yevgeny
Weinbaum, Carolyn
Pick, Edgar
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (32) : 22257 - 22271
[8] Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output
Zhou, Yong
Prakash, Priyanka
Liang, Hong
Cho, Kwang-Jin
Gorfe, Alemayehu A.
Hancock, John F.
[J]. CELL, 2017, 168 (1-2) : 239 - +
[9] Ras nanoclusters: Versatile lipid-based signaling platforms
Zhou, Yong
Hancock, John F.
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2015, 1853 (04): : 841 - 849

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