Camptothecin and cisplatin upregulate ABCG2 and MRP2 expression by activating the ATMUNF-κB pathway in lung cancer cells

被引：48

作者：

Ke, Shi Zhong ^{[1
]}

Ni, Xiao Yan ^{[1
]}

Zhang, Yue Hua ^{[1
]}

Wang, Yi Nan ^{[1
]}

Wu, Bin ^{[2
]}

Gao, Feng Guang ^{[1
]}

机构：

[1] Xiamen Univ, Coll Med, Dept Immunol, Xiamen 361005, Peoples R China

[2] Shanghai Jiao Tong Univ, Affiliated Renji Hosp, Dept Pharmacol, Shanghai 200030, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2013年 / 42卷 / 04期

基金：

中国国家自然科学基金;

关键词：

ataxia telangietisa mutanted; NF-kappa B; ABCG2; MRP2; lung cancer; INTERSTRAND CROSS-LINKS; MULTIDRUG-RESISTANCE; DNA-DAMAGE; IN-VITRO; ATAXIA-TELANGIECTASIA; DRUG-RESISTANCE; DENDRITIC CELLS; PROTEIN-KINASE; THERAPY; OVEREXPRESSION;

D O I：

10.3892/ijo.2013.1805

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multidrug resistance (MDR) formation is an important problem in lung cancer chemotherapy. Our study showed that both camptothecin and cisplatin could not only induce ATM and NF-kappa B activation but also upregulate expression of the MDR-related genes ABCG2, MRP2 in NCI-H446 cells. Moreover, camptothecin and cisplatin-induced ABCG2 and MRP2 upregulation could be impaired by ATM and NF-kappa B inhibitors, indicating a relationship between ATM, NF-kappa B activation and MDR formation in lung cancer chemotherapy. Our study indicates that ATM may serve as a potential molecular target for MDR formation in lung cancer chemotherapy.

引用

页码：1289 / 1296

页数：8

共 43 条

[21] Multidrug resistance-associated protein 2 determines the efficacy of cisplatin in patients with hepatocellular carcinoma [J].

Korita, Pavel V. ;

Wakai, Toshifumi ;

Shirai, Yoshio ;

Matsuda, Yasunobu ;

Sakata, Jun ;

Takamura, Masaaki ;

Yano, Masahiko ;

Sanpei, Ayumi ;

Aoyagi, Yutaka ;

Hatakeyama, Katsuyoshi ;

Ajioka, Yoichi .

ONCOLOGY REPORTS, 2010, 23 (04) :965-972

[22] Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy [J].

Li, Feng ;

Sethi, Gautam .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2010, 1805 (02) :167-180

[23] The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy [J].

Lin, Yong ;

Bai, Lang ;

Chen, Wenjie ;

Xu, Shanling .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2010, 14 (01) :45-55

[24] KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma [J].

Ling, Jianhua ;

Kang, Ya'an ;

Zhao, Ruiying ;

Xia, Qianghua ;

Lee, Dung-Fang ;

Chang, Zhe ;

Li, Jin ;

Peng, Bailu ;

Fleming, Jason B. ;

Wang, Huamin ;

Liu, Jinsong ;

Lemischka, Ihor R. ;

Hung, Mien-Chie ;

Chiao, Paul J. .

CANCER CELL, 2012, 21 (01) :105-120

[25] NF-κB as a target for cancer therapy [J].

Melisi, Davide ;

Chiao, Paul J. .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2007, 11 (02) :133-144

[26] Nuclear initiated NF-κB signaling: NEMO and ATM take center stage [J].

Miyamoto, Shigeki .

CELL RESEARCH, 2011, 21 (01) :116-130

[27]

Robey RW, 2001, CLIN CANCER RES, V7, P145

[28] Doxorubicin induces expression of multidrug resistance-associated protein 1 in human small cell lung cancer cell lines by the c-jun N-terminal kinase pathway [J].

Shinoda, C ;

Maruyama, M ;

Fujishita, T ;

Dohkan, J ;

Oda, H ;

Shinoda, K ;

Yamada, T ;

Miyabayashi, K ;

Hayashi, R ;

Kawagishi, Y ;

Fujita, T ;

Matsui, S ;

Sugiyama, E ;

Muraguchi, A ;

Kobayashi, M .

INTERNATIONAL JOURNAL OF CANCER, 2005, 117 (01) :21-31

[29] Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples [J].

Spanswick, Victoria J. ;

Lowe, Helen L. ;

Newton, Claire ;

Bingham, John P. ;

Bagnobianchi, Alessia ;

Kiakos, Konstantinos ;

Craddock, Charles ;

Ledermann, Jonathan A. ;

Hochhauser, Daniel ;

Hartley, John A. .

BMC CANCER, 2012, 12

[30] Lung cancer: Progress in diagnosis, staging and therapy [J].

Spiro, Stephen G. ;

Tanner, Nichole T. ;

Silvestri, Gerard A. ;

Janes, Sam M. ;

Lim, Eric ;

Vansteenkiste, Johan F. ;

Pirker, Robert .

RESPIROLOGY, 2010, 15 (01) :44-50

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