Melanoma immunoediting by NK cells

被引：21
作者：
Balsamo, Mirna [1 ]
Pietra, Gabriella [1 ]
Vermi, William [2 ]
Moretta, Lorenzo [3 ]
Mingari, Maria Cristina [1 ,4 ,5 ]
Vitale, Massimo [5 ]
机构：
[1] Univ Genoa, Dipartimento Med Sperimentale, Genoa, Italy
[2] Spedali Civil Brescia, Serv Anat Patol, I-25125 Brescia, Italy
[3] Ist Giannina Gaslini, I-16148 Genoa, Italy
[4] Ctr Eccellenza Ric Biomed, Genoa, Italy
[5] Ist Nazl Ric Canc, IRCCS Azienda Osped Univ San Martino IST, I-16132 Genoa, Italy
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 09期
关键词：
Cytokines; HLA-I; immunoediting; melanoma; NK cells; CANCER; TUMOR;
D O I：
10.4161/onci.21456
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The immune system can control the early steps of tumor growth, but it may also induce phenotypic/functional changes of malignant cells during tumor progression, favoring immunoescape mechanisms. In a recent study, we revealed how natural killer (NK) cells can participate in such an immunoediting process, by rendering melanoma cells resistant to NK-mediated killing.
引用
收藏
页码：1607 / 1609
页数：3
相关论文
共 10 条
[1]   Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor [J].
Balsamo, Mirna ;
Vermi, William ;
Parodi, Monica ;
Pietra, Gabriella ;
Manzini, Claudia ;
Queirolo, Paola ;
Lonardi, Silvia ;
Augugliaro, Raffaella ;
Moretta, Alessandro ;
Facchetti, Fabio ;
Moretta, Lorenzo ;
Mingari, Maria Cristina ;
Vitale, Massimo .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (07) :1833-1842
[2]   Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity [J].
Balsamo, Mirna ;
Scordamaglia, Francesca ;
Pietra, Gabriella ;
Manzini, Claudia ;
Cantoni, Claudia ;
Boitano, Monica ;
Queirolo, Paola ;
Vermi, William ;
Facchetti, Fabio ;
Moretta, Alessandro ;
Moretta, Lorenzo ;
Mingari, Maria Cristina ;
Vitale, Massimo .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (49) :20847-20852
[3]   Beyond the increasing complexity of the immunomodulatory HLA-G molecule [J].
Carosella, Edgardo D. ;
Favier, Benoit ;
Rouas-Freiss, Nathalie ;
Moreau, Philippe ;
LeMaoult, Joel .
BLOOD, 2008, 111 (10) :4862-4870
[4]   The immune contexture in human tumours: impact on clinical outcome [J].
Fridman, Wolf Herman ;
Pages, Franck ;
Sautes-Fridman, Catherine ;
Galon, Jerome .
NATURE REVIEWS CANCER, 2012, 12 (04) :298-306
[5]   Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation [J].
Moretta, Lorenzo ;
Locatelli, Franco ;
Pende, Daniela ;
Marcenaro, Emanuela ;
Mingari, Maria Cristina ;
Moretta, Alessandro .
BLOOD, 2011, 117 (03) :764-771
[6]   Friends or foes - Bipolar effects of the tumour stroma in cancer [J].
Mueller, MM ;
Fusenig, NE .
NATURE REVIEWS CANCER, 2004, 4 (11) :839-849
[7]   Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity [J].
Pietra, Gabriella ;
Manzini, Claudia ;
Rivara, Silvia ;
Vitale, Massimo ;
Cantoni, Claudia ;
Petretto, Andrea ;
Balsamo, Mirna ;
Conte, Romana ;
Benelli, Roberto ;
Minghelli, Simona ;
Solari, Nicola ;
Gualco, Marina ;
Queirolo, Paola ;
Moretta, Lorenzo ;
Mingari, Maria Cristina .
CANCER RESEARCH, 2012, 72 (06) :1407-1415
[8]   Natural killer cell-directed therapies: moving from unexpected results to successful strategies [J].
Terme, Magali ;
Ullrich, Evelyn ;
Delahaye, Nicolas F. ;
Chaput, Nathalie ;
Zitvogel, Laurence .
NATURE IMMUNOLOGY, 2008, 9 (05) :486-494
[9]   Natural Innate and Adaptive Immunity to Cancer [J].
Vesely, Matthew D. ;
Kershaw, Michael H. ;
Schreiber, Robert D. ;
Smyth, Mark J. .
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 :235-271
[10]   Cancer despite immunosurveillance: immunoselection and immunosubversion [J].
Zitvogel, Laurence ;
Tesniere, Antoine ;
Kroemer, Guido .
NATURE REVIEWS IMMUNOLOGY, 2006, 6 (10) :715-727
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