The role of Type I interferons in immunoregulation of breast cancer metastasis to the bone

被引：17

作者：

Slaney, Clare Y. ^{[1
,2
]}

Moeller, Andreas ^{[1
,2
,3
]}

Hertzog, Paul J. ^{[5
]}

Parker, Belinda S. ^{[1
,2
,4
]}

机构：

[1] Peter MacCallum Canc Ctr, Div Res, Melbourne, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3052, Australia

[3] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia

[4] Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic 3052, Australia

[5] Monash Univ, Monash Inst Med Res, Ctr Innate Immun & Infect Dis, Clayton, Vic, Australia

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 01期

关键词：

bone metastasis; breast cancer; interferon; tumor immune surveillance;

D O I：

10.4161/onci.22339

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer spread to distant sites is often incurable. Our recent findings demonstrate that Type I interferons secreted by tumor cells induce anti-metastatic immune responses that prevent breast cancer metastasis to the bone. This provides novel insights into the importance of the crosstalk between neoplastic and immune cells in the metastatic process.

引用

页数：3

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