Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins

被引：724

作者：

Maddocks, Sarah E. ^{[1
]}

Oyston, Petra C. F. ^{[2
]}

机构：

[1] Univ Bristol, Dept Oral & Dent Sci, Bristol BS1 2LY, Avon, England

[2] DSTL Porton Down, Salisbury SP4 0JQ, Wilts, England

来源：

MICROBIOLOGY-SGM | 2008年 / 154卷

关键词：

D O I：

10.1099/mic.0.2008/022772-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The LysR family of transcriptional regulators represents the most abundant type of transcriptional regulator in the prokaryotic kingdom. Members of this family have a conserved structure with an N-terminal DNA-binding helix-turn-helix motif and a C-terminal co-inducer-binding domain. Despite considerable conservation both structurally and functionally, LysR-type transcriptional regulators (LTTRs) regulate a diverse set of genes, including those involved in virulence, metabolism, quorum sensing and motility. Numerous structural and transcriptional studies of members of the LTTR family are helping to unravel a compelling paradigm that has evolved from the original observations and conclusions that were made about this family of transcriptional regulators.

引用

页码：3609 / 3623

页数：15

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