Pneumococci in the African Meningitis Belt: Meningitis Incidence and Carriage Prevalence in Children and Adults

被引：48

作者：

Mueller, Judith E. ^{[1
]}

Yaro, Seydou ^{[2
]}

Ouedraogo, Macaire S. ^{[3
]}

Levina, Natalia ^{[4
]}

Njanpop-Lafourcade, Berthe-Marie ^{[1
]}

Tall, Haoua ^{[1
]}

Idohou, Regina S. ^{[1
]}

Sanou, Oumarou ^{[1
]}

Kroman, Sita S. ^{[1
]}

Drabo, Aly ^{[2
]}

Nacro, Boubacar ^{[3
]}

Millogo, Athanase ^{[3
]}

van der Linden, Mark ^{[4
]}

Gessner, Bradford D. ^{[1
]}

机构：

[1] Agence Med Prevent, Paris, France

[2] Ctr Muraz, Bobo Dioulasso, Burkina Faso

[3] Ctr Hosp Univ Sourou Sanou, Bobo Dioulasso, Burkina Faso

[4] GNRC Streptococci, Aachen, Germany

来源：

PLOS ONE | 2012年 / 7卷 / 12期

基金：

英国医学研究理事会;

关键词：

STREPTOCOCCUS-PNEUMONIAE; BURKINA-FASO; SEROTYPE-1; NASOPHARYNGEAL; SURVEILLANCE; OUTBREAK; AGE;

D O I：

10.1371/journal.pone.0052464

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: The development of optimal vaccination strategies for pneumococcal conjugate vaccines requires serotype-specific data on disease incidence and carriage prevalence. This information is lacking for the African meningitis belt. Methods: We conducted hospital-based surveillance of acute bacterial meningitis in an urban and rural population of Burkina Faso during 2007-09. Cerebrospinal fluid was evaluated by polymerase chain reaction for species and serotype. In 2008, nasopharyngeal swabs were obtained from a representative population sample (1 month to 39 years; N = 519) and additional oropharyngeal swabs from 145 participants. Swabs were evaluated by culture. Results: Annual pneumococcal meningitis incidence rates were highest among <6-month-old (58/100,000) and 15- to 19-year-old persons (15/100,000). Annual serotype 1 incidence was around 5/100,000 in all age groups. Pneumococcal carriage prevalence in nasopharyngeal swabs was 63% among <5-year-old children and 22% among >= 5-year-old persons, but adding oropharyngeal to nasopharyngeal swabs increased the estimated carriage prevalence by 60%. Serotype 1 showed high propensity for invasive disease, particularly among persons aged >= 5 years. Conclusions: Serotype 1 causes the majority of cases with a relatively constant age-specific incidence. Pneumococcal carriage is common in all age groups including adults. Vaccination programs in this region may need to include older target age groups for optimal impact on disease burden.

引用

页数：9

共 30 条

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