Cutaneous presentation of progressive disseminated histoplasmosis nine years after renal transplantation

被引:8
作者
Rosado-Odom, V. M. [1 ]
Daoud, J. [1 ]
Johnson, R. [1 ]
Allen, S. D. [1 ]
Lockhart, S. R. [2 ]
Iqbal, N. [2 ]
Shieh, W. -J. [3 ]
Zaki, S. [3 ]
Sharfuddin, A. A. [1 ]
机构
[1] Indiana Univ Sch Med, Dept Med, Indianapolis, IN USA
[2] Ctr Dis Control & Prevent CDC, Mycot Dis Branch, Atlanta, GA USA
[3] CDC, Infect Dis Pathol Branch, Atlanta, GA 30333 USA
关键词
histoplasmosis; cutaneous lesion; renal transplant; Histoplasma capsulatum; HUMAN-IMMUNODEFICIENCY-VIRUS; RECIPIENTS; CELLULITIS; MANAGEMENT; CAPSULATUM; DIAGNOSIS; ITRACONAZOLE; INFECTION;
D O I
10.1111/tid.12059
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Initial presentation of invasive fungal infections such as histoplasmosis can include non-specific clinical manifestations, especially in immunocompromised patients. A high index of suspicion is required to identify atypical manifestations of these diseases, which carry a high risk of mortality, if the diagnosis is delayed or missed. We describe a case of a kidney transplant recipient with cutaneous lesions as initial manifestation of progressive disseminated histoplasmosis where a skin biopsy was crucial to an early diagnosis.
引用
收藏
页码:E64 / E69
页数:6
相关论文
共 26 条
  • [1] Cellulitis: diagnosis and management
    Bailey, Elizabeth
    Kroshinsky, Daniela
    [J]. DERMATOLOGIC THERAPY, 2011, 24 (02) : 229 - 239
  • [2] Endemic and opportunistic infections in Brazilian solid organ transplant recipients
    Batista, M. V.
    Pierrotti, L. C.
    Abdala, E.
    Clemente, W. T.
    Girao, E. S.
    Rosa, D. R. T.
    Ianhez, L. E.
    Bonazzi, P. R.
    Lima, A. S.
    Fernandes, P. F. C. B. C.
    Padua-Neto, M. V.
    Bacchella, T.
    Oliveira, A. P. P.
    Viana, C. F. G.
    Ferreira, M. S.
    Shikanai-Yasuda, M. A.
    [J]. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2011, 16 (09) : 1134 - 1142
  • [3] CUTANEOUS LESIONS OF DISSEMINATED HISTOPLASMOSIS IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTED PATIENTS
    COHEN, PR
    BANK, DE
    SILVERS, DN
    GROSSMAN, ME
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1990, 23 (03) : 422 - 428
  • [4] Histoplasmosis in Solid Organ Transplant Recipients: 10 Years of Experience at a Large Transplant Center in an Endemic Area
    Cuellar-Rodriguez, J.
    Avery, R. K.
    Lard, M.
    Budev, M.
    Gordon, S. M.
    Shrestha, N. K.
    van Duin, D.
    Oethinger, M.
    Mawhorter, S. D.
    [J]. CLINICAL INFECTIOUS DISEASES, 2009, 49 (05) : 710 - 716
  • [5] DISSEMINATED HISTOPLASMOSIS IN RENAL-TRANSPLANT RECIPIENTS
    DAVIES, SF
    SAROSI, GA
    PETERSON, PK
    KHAN, M
    HOWARD, RJ
    SIMMONS, RL
    NAJARIAN, JS
    [J]. AMERICAN JOURNAL OF SURGERY, 1979, 137 (05) : 686 - 691
  • [6] Marked increase in steady-state serum levels achieved with itraconazole oral solution compared with capsule formulation
    Freeman, Josh
    Heshmati, Amy
    Holland, David
    Ticehurst, Rob
    Lang, Selwyn
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 60 (04) : 908 - 909
  • [7] Histoplasmosis in solid organ transplant recipients at a large Midwestern university transplant center
    Freifeld, AG
    Iwen, PC
    Lesiak, BL
    Gilroy, RK
    Stevens, RB
    Kalil, AC
    [J]. TRANSPLANT INFECTIOUS DISEASE, 2005, 7 (3-4) : 109 - 115
  • [8] Histoplasmosis in solid organ transplant recipients: early diagnosis and treatment
    Freifeld, Alison G.
    Wheat, L. Joseph
    Kaul, Daniel R.
    [J]. CURRENT OPINION IN ORGAN TRANSPLANTATION, 2009, 14 (06) : 601 - 605
  • [9] Phylogeography of the fungal pathogen Histoplasma capsulatum
    Kasuga, T
    White, TJ
    Koenig, G
    Mcewen, J
    Restrepo, A
    Castañeda, E
    Lacaz, CD
    Heins-Vaccari, EM
    De Freitas, RS
    Zancopé-Oliveira, RM
    Qin, ZY
    Negroni, R
    Carter, DA
    Mikami, Y
    Tamura, M
    Taylor, ML
    Miller, GF
    Poonwan, N
    Taylor, JW
    [J]. MOLECULAR ECOLOGY, 2003, 12 (12) : 3383 - 3401
  • [10] Voriconazole and itraconazole in lung transplant recipients receiving tacrolimus (FK 506): efficacy and drug interaction
    Kramer, Mordechai R.
    Amital, Anat
    Fuks, Leonardo
    Shitrit, David
    [J]. CLINICAL TRANSPLANTATION, 2011, 25 (02) : E163 - E167