Water-soluble platinum(II) complexes of reduced amino acid Schiff bases: synthesis, characterization, and antitumor activity

被引：31
|
作者：
Li, Li-Jun [1 ]
Wang, Cheng [1 ]
Tian, Chao [1 ]
Yang, Xiao-Yan [1 ]
Hua, Xing-Xing [1 ]
Du, Jian-Long [1 ]
机构：
[1] Hebei Univ, Chem Biol Key Lab Hebei Prov, Baoding 071002, Peoples R China
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2013年 / 39卷 / 02期
关键词：
Water-soluble platinum(II) complexes; Reduced amino acid Schiff bases; DNA interaction; Antitumor activity; DNA; COMBINATION; TOXICITY; AGENTS;
D O I：
10.1007/s11164-012-0593-y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of water-soluble platinum(II) complexes of reduced amino acid Schiff bases were synthesized as potential anticancer agents and characterized by H-1 NMR, EA, MS, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by the MTT assay. The cytotoxicity of one complex (5g) is better than that of cisplatin against BGC-823 and HL-60 cell lines, and show close cytotoxic effect against Bel-7402 cell line.
引用
收藏
页码：733 / 746
页数：14
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