Evidence for a Common Endocannabinoid-Related Pathomechanism in Autism Spectrum Disorders

被引：11
作者：
Krueger, Dilja D. [1 ]
Brose, Nils [1 ]
机构：
[1] Max Planck Inst Expt Med, Dept Mol Neurobiol, D-37075 Gottingen, Germany
来源：
NEURON | 2013年 / 78卷 / 03期
关键词：
SYNAPTIC PATHOPHYSIOLOGY; NEUROLIGINS; MUTATIONS; MODEL; MICE;
D O I：
10.1016/j.neuron.2013.04.030
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this issue of Neuron, Foldy et al. (2013) report that endocannabinoid-mediated signaling at inhibitory synapses is dysregulated in mouse models of autism-associated Neuroligin-3 mutations. These findings carry implications regarding the pathophysiology of autism spectrum disorders and the development of treatment strategies.
引用
收藏
页码：408 / 410
页数：3
相关论文
共 15 条
  • [1] Mutations causing syndromic autism define an axis of synaptic pathophysiology
    Auerbach, Benjamin D.
    Osterweil, Emily K.
    Bear, Mark F.
    [J]. NATURE, 2011, 480 (7375) : 63 - U222
  • [2] Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism
    Baudouin, Stephane J.
    Gaudias, Julien
    Gerharz, Stefan
    Hatstatt, Laetitia
    Zhou, Kuikui
    Punnakkal, Pradeep
    Tanaka, Kenji F.
    Spooren, Will
    Hen, Rene
    De Zeeuw, Chris I.
    Vogt, Kaspar
    Scheiffele, Peter
    [J]. SCIENCE, 2012, 338 (6103) : 128 - 132
  • [3] The mGIuR theory of fragile X mental retardation
    Bear, MF
    Huber, KM
    Warren, ST
    [J]. TRENDS IN NEUROSCIENCES, 2004, 27 (07) : 370 - 377
  • [4] Busquets-Garcia A., 2013, NAT MED
  • [5] Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
    Etherton, Mark
    Foeldy, Csaba
    Sharma, Manu
    Tabuchi, Katsuhiko
    Liu, Xinran
    Shamloo, Mehrdad
    Malenka, Robert C.
    Suedhof, Thomas C.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (33) : 13764 - 13769
  • [6] Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling
    Foeldy, Csaba
    Malenka, Robert C.
    Suedhof, Thomas C.
    [J]. NEURON, 2013, 78 (03) : 498 - 509
  • [7] Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
    Jamain, S
    Quach, H
    Betancur, C
    Råstam, M
    Colineaux, C
    Gillberg, IC
    Soderstrom, H
    Giros, B
    Leboyer, M
    Gillberg, C
    Bourgeron, T
    Gillberg, C
    Råstam, M
    Gillberg, C
    Nydén, A
    Söderström, H
    Leboyer, M
    Betancur, C
    Philippe, A
    Giros, B
    Colineaux, C
    Cohen, D
    Chabane, N
    Mouren-Siméoni, MC
    Brice, A
    Sponheim, E
    Spurkland, I
    Skjeldal, OH
    Coleman, M
    Pearl, PL
    Cohen, IL
    Tsiouris, J
    Zappella, M
    Menchetti, G
    Pompella, A
    Aschauer, H
    Van Maldergem, L
    [J]. NATURE GENETICS, 2003, 34 (01) : 27 - 29
  • [8] Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome
    Jung, Kwang-Mook
    Sepers, Marja
    Henstridge, Christopher M.
    Lassalle, Olivier
    Neuhofer, Daniela
    Martin, Henry
    Ginger, Melanie
    Frick, Andreas
    DiPatrizio, Nicholas V.
    Mackie, Ken
    Katona, Istvan
    Piomelli, Daniele
    Manzoni, Olivier J.
    [J]. NATURE COMMUNICATIONS, 2012, 3
  • [9] Multiple Functions of Endocannabinoid Signaling in the Brain
    Katona, Istvan
    Freund, Tamas F.
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, VOL 35, 2012, 35 : 529 - 558
  • [10] The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses
    Krueger, Dilja D.
    Tuffy, Liam P.
    Papadopoulos, Theofilos
    Brose, Nils
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2012, 22 (03) : 412 - 422
12