Bone metastases from head and neck malignancies: Prognostic factors and skeletal-related events

被引：12

作者：

Grisanti, Salvatore ^{[1
]}

Bianchi, Susanna ^{[1
]}

Locati, Laura D. ^{[2
]}

Triggiani, Luca ^{[3
]}

Vecchio, Stefania ^{[4
,5
]}

Bonetta, Alberto ^{[6
]}

Bergamini, Cristiana ^{[2
]}

Conte, Pierfranco ^{[7
]}

Airoldi, Mario ^{[8
]}

Merlano, Marco ^{[9
]}

Carlini, Paolo ^{[10
]}

Ibrahim, Toni ^{[11
]}

Rossetto, Ciro ^{[12
]}

Alfieri, Salvatore ^{[2
]}

Pronzato, Paolo ^{[4
,5
]}

Tonoli, Sandro ^{[6
]}

Maroldi, Roberto ^{[13
]}

Nicolai, Piero ^{[14
]}

Resteghini, Carlo ^{[2
]}

Magrini, Stefano M. ^{[3
]}

Berruti, Alfredo ^{[1
]}

机构：

[1] Univ Brescia, Dept Med & Surg Specialties, Med Oncol Unit, ASST Spedali Civili,Radiol Sci & Publ Hlth, Brescia, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Med Oncol Head & Neck Unit, Milan, Italy

[3] Univ Brescia, Dept Med & Surg Specialties, Radiat Oncol Unit, ASST Spedali Civili,Radiol Sci & Publ Hlth, Brescia, Italy

[4] IRCCS San Martino, IST Natl Canc Inst, Med Oncol Unit, Genoa, Italy

[5] Univ Genoa, Genoa, Italy

[6] Ist Ospitalieri Cremona ASST, Dept Radiotherapy, Cremona, Italy

[7] Univ Padua, Div Med Oncol 2, Ist Oncol Veneto IRCCS, Dept Surg Oncol & Gastroenterol, Padua, Italy

[8] Citta Salute & Sci Hosp Turin, Med Oncol Div 2, Turin, Italy

[9] AOS Croce & Carle Teaching Hosp, Med Oncol, Cuneo, Italy

[10] Ist Nazl Tumori Regina Elena, Med Oncol, Rome, Italy

[11] Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Osteoncol & Rare Tumors Ctr, Meldola, Italy

[12] Univ Hosp Santa Maria Misericordia, Dept Oncol, Udine, Italy

[13] Univ Brescia, Dept Med & Surg Specialties, Radiol Unit, ASST Spedali Civili,Radiol Sci & Publ Hlth, Brescia, Italy

[14] Univ Brescia, Dept Med & Surg Specialties, Unit Otorhinolaryngol Head & Neck Surg, ASST Spedali Civili,Radiol Sci & Publ Hlth, Brescia, Italy

来源：

PLOS ONE | 2019年 / 14卷 / 03期

关键词：

SQUAMOUS-CELL CARCINOMA; CANCER; SURVIVAL; CHEMOTHERAPY;

D O I：

10.1371/journal.pone.0213934

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background We conducted a multicenter retrospective analysis to describe the characteristics, frequency of skeletal-related events (SREs), and prognosis of head and neck cancer (HNC) in patients with bone metastases (BM). Patients and methods The data of 192 HNC patients with BMs were collected. Analyses were conducted separately in 64 nasopharyngeal cancer (NPC) patients and in 128 non-NPC patients. Results SREs occurred in 34 (27%) non-NPC and in 6 (9%) NPC patients, respectively. Median overall survival (OS) was 25 and 6 months in NPC and non-NPC patients, respectively. Locoregional recurrence (hazard ratio [HR] 2.33, 95% confidence interval (CI) 1.1-4.93), synchronous BM (HR 0.25, 95% CI 0.59-0.71) and bone-directed therapies (BDT) (HR 0.26, 95% CI 0.10-0.68) were independent prognostic factors for OS in NPC patients. Combined bone radiotherapy (RT) and BDT in NPC patients obtained longer survival (38 months) than either therapy alone (25 months) or neither of these therapies (8 months). Conclusions Patients with BMs from non-NPC have a poor prognosis and are at high risk of SREs. NPC patients with BMs are at relatively low risk of SREs. BDT may potentially improve survival, particularly when combined with bone RT. This last finding deserves prospective confirmation.

引用

页数：15

共 27 条

[1] A retrospective study of incidence of bone metastasis in head and neck cancer [J].