SNPing cancer in the bud: MicroRNA and microRNA-target site polymorphisms as diagnostic and prognostic biomarkers in cancer

被引：79

作者：

Salzman, David W. ^{[1
]}

Weidhaas, Joanne B. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06510 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2013年 / 137卷 / 01期

关键词：

MicroRNA; miRNA; Polymorphism; Single nucleotide polymorphism; SNP; Cancer; HUMAN LUNG CANCERS; BREAST-CANCER; LET-7; MICRORNA; FUNCTIONAL POLYMORPHISM; REGULATORY VARIATION; GENE-EXPRESSION; 3'-UNTRANSLATED REGION; REDUCED EXPRESSION; NATURAL-SELECTION; GENOME SEQUENCE;

D O I：

10.1016/j.pharmthera.2012.08.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

MicroRNAs are master regulators of gene expression and control many biological pathways such as cell growth, differentiation and apoptosis. Deregulation of microRNA expression and activity results in a myriad of diseases including cancer. Recently, several reports have indicated that single nucleotide polymorphisms (SNPs) in microRNAs and microRNA-target sites impact microRNA biology and associate with cancer risk, treatment response and outcome. In this review we will describe these findings and discuss the possible future of utilizing these SNPs as diagnostic and prognostic markers in the clinic. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：55 / 63

页数：9

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