Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants

被引：24

作者：

Asbury, Michelle R. ^{[1
,2
]}

Shama, Sara ^{[1
,2
]}

Sa, Jong Yup ^{[1
,2
]}

Bando, Nicole ^{[1
,2
]}

Butcher, James ^{[3
,4
]}

Comelli, Elena M. ^{[1
,5
]}

Copeland, Julia K. ^{[6
]}

Forte, Victoria ^{[1
,2
]}

Kiss, Alex ^{[7
,8
]}

Sherman, Philip M. ^{[1
,9
,10
,11
,12
]}

Stintzi, Alain ^{[3
,4
]}

Taibi, Amel ^{[1
]}

Tomlinson, Christopher ^{[1
,2
,5
,13
,14
]}

Unger, Sharon ^{[1
,13
,14
,15
,16
]}

Wang, Pauline W. ^{[6
]}

O'Connor, Deborah L. ^{[1
,2
,5
,15
,16
]}

机构：

[1] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 1A8, Canada

[2] Hosp Sick Children, SickKids Res Inst, Translat Med Program, Toronto, ON M5G 0A4, Canada

[3] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1N 6N5, Canada

[4] Univ Ottawa, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada

[5] Univ Toronto, Joannah & Brian Lawson Ctr Child Nutr, Toronto, ON M5S 1A8, Canada

[6] Univ Toronto, Ctr Anal Genome Evolut & Funct, Toronto, ON M5S 3B2, Canada

[7] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON M5T 3M6, Canada

[8] Sunnybrook Res Inst, Evaluat & Clin Sci, Toronto, ON M4N 3M5, Canada

[9] Hosp Sick Children, SickKids Res Inst, Cell Biol Program, Toronto, ON M5G 0A4, Canada

[10] Hosp Sick Children, Gastroenterol Hepatol & Nutr, Toronto, ON M5G 1X8, Canada

[11] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada

[12] Univ Toronto, Fac Dent, Toronto, ON M5G 1X3, Canada

[13] Univ Toronto, Dept Pediat, Toronto, ON M5G 1X8, Canada

[14] Hosp Sick Children, Div Neonatol, Toronto, ON M5G 1X8, Canada

[15] Sinai Hlth, Dept Pediat, Toronto, ON M5G 1X5, Canada

[16] Rogers Hixon Ontario Human Milk Bank, Toronto, ON M5G 1X5, Canada

来源：

CELL HOST & MICROBE | 2022年 / 30卷 / 09期

基金：

加拿大健康研究院;

关键词：

PRETERM INFANTS; MOTHERS; SEQUENCES; GROWTH; TIME;

D O I：

10.1016/j.chom.2022.07.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nutrient fortifiers are added to human milk to support the development of very-low-birth-weight infants. Currently, bovine-milk-based fortifiers (BMBFs) are predominantly administered, with increasing interest in adopting human-milk-based fortifiers (HMBFs). Although beneficial for growth, their effects on the gastrointestinal microbiota are unclear. This triple-blind, randomized clinical trial (NCT02137473) tested how nutrient-enriching human milk with HMBF versus BMBF affects the gastrointestinal microbiota of infants born < 1,250 g during hospitalization. HMBF-fed infants (n = 63, n = 269 stools) showed lower microbial diversity, altered microbial community structure, and changes in predicted microbial functions compared with BMBF-fed infants (n = 56, n = 239 stools). HMBF-fed infants had higher relative and normalized abundances of unclassified Enterobacteriaceae and lower abundances of Clostridium sensu stricto. Post hoc analyses identified dose-dependent relationships between individual feed components (volumes of mother's milk, donor milk, and fortifiers) and the microbiota. These results highlight how nutrient fortifiers impact the microbiota of very-low-birth-weight infants during a critical developmental window.

引用

页码：1328 / +

页数：17

共 68 条

[1] Human Milk-Based or Bovine Milk-Based Fortifiers Differentially Impact the Development of the Gut Microbiota of Preterm Infants [J].