Radionuclide 131I labeled reduced graphene oxide for nuclear imaging guided combined radio- and photothermal therapy of cancer

被引：173

作者：

Chen, Lei ^{[1
,2
,4
]}

Zhong, Xiaoyan ^{[1
,2
]}

Yi, Xuan ^{[1
,2
]}

Huang, Min ^{[4
]}

Ning, Ping ^{[1
,2
]}

Liu, Teng ^{[3
]}

Ge, Cuicui ^{[1
,2
]}

Chai, Zhifang ^{[1
,2
]}

Liu, Zhuang ^{[3
]}

Yang, Kai ^{[1
,2
]}

机构：

[1] Soochow Univ, Coll Med, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med,Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Coll Med, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med,Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China

[3] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China

[4] East Dist Suzhou Municipal Hosp, Suzhou 215001, Jiangsu, Peoples R China

来源：

BIOMATERIALS | 2015年 / 66卷

基金：

美国国家科学基金会;

关键词：

Nano-graphene; Radiotherapy; Combined therapy; Radio labeling; Gamma imaging; ANTICANCER DRUG; TUMOR VASCULATURE; DELIVERY; NANOSHEETS; RADIATION; BIOCOMPATIBILITY; RADIOTHERAPY; CHEMISTRY; MODALITY; MICE;

D O I：

10.1016/j.biomaterials.2015.06.043

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Nano-graphene and its derivatives have attracted great attention in biomedicine, including their applications in cancer theranostics. In this work, we develop 131I labeled, polyethylene glycol (PEG) coated reduced nano-graphene oxide (RGO), obtaining 131I-RGO-PEG for nuclear imaging guided combined radiotherapy and photothermal therapy of cancer. Compared with free 131I, 131IRGO- PEG exhibits enhanced cellular uptake and thus improved radio-therapeutic efficacy against cancer cells. As revealed by gamma imaging, efficient tumor accumulation of 131I-RGO-PEG is observed after its intravenous injection. While RGO exhibits strong near-infrared (NIR) absorbance and could induce effective photothermal heating of tumor under NIR light irradiation, 131I is able to emit high-energy X-ray to induce cancer killing as the result of radio ionization effect. By utilizing the combined photothermal therapy and radiotherapy, both of which are delivered by a single agent 131IRGO- PEG, effective elimination of tumors is achieved in our animal tumor model experiments. Toxicology studies further indicate that 131I-RGO-PEG induces no appreciable toxicity to mice at the treatment dose. Our work demonstrates the great promise of combing nuclear medicine and photothermal therapy as a novel therapeutic strategy to realize synergistic efficacy in cancer treatment. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.

引用

页码：21 / 28

页数：8

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