Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents

被引：267

作者：

Clough, Thomas J. ^{[1
]}

Jiang, Lijun ^{[1
,2
]}

Wong, Ka-Leung ^{[2
]}

Long, Nicholas J. ^{[1
]}

机构：

[1] Imperial Coll London, Dept Chem, Mol Sci Res Hub, White City Campus, London W12 0BZ, England

[2] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

基金：

英国工程与自然科学研究理事会;

关键词：

POLYMETHYLATED DOTA LIGANDS; RELAXIVITY MRI AGENTS; BLOOD-POOL AGENT; LANTHANIDE(III) COMPLEXES; THERMODYNAMIC STABILITY; STRUCTURAL-PROPERTIES; KINETIC INERTNESS; WATER EXCHANGE; GD3+ COMPLEXES; COORDINATION CHEMISTRY;

D O I：

10.1038/s41467-019-09342-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gadolinium(III) complexes have been widely utilised as magnetic resonance imaging (MRI) contrast agents for decades. In recent years however, concerns have developed about their toxicity, believed to derive from demetallation of the complexes in vivo, and the relatively large quantities of compound required for a successful scan. Recent efforts have sought to enhance the relaxivity of trivalent gadolinium complexes without sacrificing their stability. This review aims to examine the strategic design of ligands synthesised for this purpose, provide an overview of recent successes in gadolinium-based contrast agent development and assess the requirements for clinical translation.

引用

页数：14

共 131 条

[1] Synthesis and NMR studies of three pyridine-containing triaza macrocyclic triacetate ligands and their complexes with lanthanide ions [J].

Aime, S ;

Botta, M ;

Crich, SG ;

Giovenzana, GB ;

Jommi, G ;

Pagliarin, R ;

Sisti, M .

INORGANIC CHEMISTRY, 1997, 36 (14) :2992-3000

[2] [GdPCP2A(H2O)2]-:: A paramagnetic contrast agent designed for improved applications in magnetic resonance imaging [J].

Aime, S ;

Botta, M ;

Frullano, L ;

Crich, SG ;

Giovenzana, G ;

Pagliarin, R ;

Palmisano, G ;

Sirtori, FR ;

Sisti, M .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (21) :4017-4024

[3] Gd(III)-based contrast agents for MRI [J].

Aime, S ;

Botta, M ;

Terreno, E .

ADVANCES IN INORGANIC CHEMISTRY - INCLUDING BIOINORGANIC STUDIES, VOL 57: RELAXOMETRY OF WATER-METAL ION INTERACTIONS, 2005, 57 :173-237

[4] Designing novel contrast agents for magnetic resonance imaging. Synthesis and relaxometric characterization of three gadolinium(III) complexes based on functionalized pyridine-containing macrocyclic ligands [J].

Aime, S ;

Gianolio, E ;

Corpillo, D ;

Cavallotti, C ;

Palmisano, G ;

Sisti, M ;

Giovenzana, GB ;

Pagliarin, R .

HELVETICA CHIMICA ACTA, 2003, 86 (03) :615-632

[5] Conformational and coordination equilibria on DOTA complexes of lanthanide metal ions in aqueous solution studied by H-1-NMR spectroscopy [J].

Aime, S ;

Botta, M ;

Fasano, M ;

Marques, MPM ;

Geraldes, CFGC ;

Pubanz, D ;

Merbach, AE .

INORGANIC CHEMISTRY, 1997, 36 (10) :2059-2068

[6] NMR-STUDY OF SOLUTION STRUCTURES AND DYNAMICS OF LANTHANIDE(III) COMPLEXES OF DOTA [J].

AIME, S ;

BOTTA, M ;

ERMONDI, G .

INORGANIC CHEMISTRY, 1992, 31 (21) :4291-4299

[7] Properties, Solution State Behavior, and Crystal Structures of Chelates of DOTMA [J].

Aime, Silvio ;

Botta, Mauro ;

Garda, Zoltan ;

Kucera, Benjamin E. ;

Tircso, Gyula ;

Young, Victor G. ;

Woods, Mark .

INORGANIC CHEMISTRY, 2011, 50 (17) :7955-7965

[8] Biodistribution of Gadolinium-Based Contrast Agents, Including Gadolinium Deposition [J].

Aime, Silvio ;

Caravan, Peter .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2009, 30 (06) :1259-1267

[9] Silencing of phosphonate-gadolinium magnetic resonance Imaging contrast by hydroxyapatite binding [J].

Alves, FC ;

Donato, P ;

Sherry, AD ;

Zaheer, A ;

Zhang, SR ;

Lubag, AJM ;

Merritt, ME ;

Lenkinski, RE ;

Frangioni, JV ;

Neves, M ;

Prata, MIM ;

Santos, AC ;

de Lima, JJP ;

Geraldes, CFGC .

INVESTIGATIVE RADIOLOGY, 2003, 38 (12) :750-760

[10] Kinetics of formation and dissociation of lanthanide(III) complexes with the 13-membered macrocyclic ligand TRITA4- [J].

Balogh, E ;

Tripier, R ;

Ruloff, R ;

Tóth, É .

DALTON TRANSACTIONS, 2005, (06) :1058-1065

← 1 2 3 4 5 6 7 8 9 10 →